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Oral spray immunization may be an alternative to intranasal vaccine delivery to induce systemic antibodies but not nasal mucosal or cellular immunity.
Bakke H, Samdal HH, Holst J, Oftung F, Haugen IL, Kristoffersen AC, Haugan A, Janakova L, Korsvold GE, Krogh G, Andersen EA, Djupesland P, Holand T, Rappuoli R, Haneberg B. Bakke H, et al. Among authors: haugen il. Scand J Immunol. 2006 Mar;63(3):223-31. doi: 10.1111/j.1365-3083.2006.01730.x. Scand J Immunol. 2006. PMID: 16499576 Free article.
Intranasal administration of a meningococcal outer membrane vesicle vaccine induces persistent local mucosal antibodies and serum antibodies with strong bactericidal activity in humans.
Haneberg B, Dalseg R, Wedege E, Høiby EA, Haugen IL, Oftung F, Andersen SR, Naess LM, Aase A, Michaelsen TE, Holst J. Haneberg B, et al. Among authors: haugen il. Infect Immun. 1998 Apr;66(4):1334-41. doi: 10.1128/IAI.66.4.1334-1341.1998. Infect Immun. 1998. PMID: 9529050 Free PMC article.
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