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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT. Trushina E, et al. Among authors: hayden m. Mol Cell Biol. 2004 Sep;24(18):8195-209. doi: 10.1128/MCB.24.18.8195-8209.2004. Mol Cell Biol. 2004. PMID: 15340079 Free PMC article.
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM. Chan EY, et al. Among authors: hayden mr. Hum Mol Genet. 2002 Aug 15;11(17):1939-51. doi: 10.1093/hmg/11.17.1939. Hum Mol Genet. 2002. PMID: 12165556
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Wellington CL, et al. Among authors: hayden mr. J Neurosci. 2002 Sep 15;22(18):7862-72. doi: 10.1523/JNEUROSCI.22-18-07862.2002. J Neurosci. 2002. PMID: 12223539 Free PMC article.
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. Singaraja RR, et al. Among authors: hayden mr. Hum Mol Genet. 2002 Nov 1;11(23):2815-28. doi: 10.1093/hmg/11.23.2815. Hum Mol Genet. 2002. PMID: 12393793
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
Metzler M, Li B, Gan L, Georgiou J, Gutekunst CA, Wang Y, Torre E, Devon RS, Oh R, Legendre-Guillemin V, Rich M, Alvarez C, Gertsenstein M, McPherson PS, Nagy A, Wang YT, Roder JC, Raymond LA, Hayden MR. Metzler M, et al. Among authors: hayden mr. EMBO J. 2003 Jul 1;22(13):3254-66. doi: 10.1093/emboj/cdg334. EMBO J. 2003. PMID: 12839988 Free PMC article.
1,734 results