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Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.
Kontoyiannis DP, Lewis RE, Alexander BD, Lortholary O, Dromer F, Gupta KL, John GT, Del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Albert ND, Wagener MM, Singh N. Kontoyiannis DP, et al. Among authors: heitman j. Antimicrob Agents Chemother. 2008 Feb;52(2):735-8. doi: 10.1128/AAC.00990-07. Epub 2007 Dec 10. Antimicrob Agents Chemother. 2008. PMID: 18070977 Free PMC article.
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
Cruz MC, Del Poeta M, Wang P, Wenger R, Zenke G, Quesniaux VF, Movva NR, Perfect JR, Cardenas ME, Heitman J. Cruz MC, et al. Among authors: heitman j. Antimicrob Agents Chemother. 2000 Jan;44(1):143-9. doi: 10.1128/AAC.44.1.143-149.2000. Antimicrob Agents Chemother. 2000. PMID: 10602736 Free PMC article.
Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
Del Poeta M, Cruz MC, Cardenas ME, Perfect JR, Heitman J. Del Poeta M, et al. Among authors: heitman j. Antimicrob Agents Chemother. 2000 Mar;44(3):739-46. doi: 10.1128/AAC.44.3.739-746.2000. Antimicrob Agents Chemother. 2000. PMID: 10681348 Free PMC article.
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
Cruz MC, Goldstein AL, Blankenship J, Del Poeta M, Perfect JR, McCusker JH, Bennani YL, Cardenas ME, Heitman J. Cruz MC, et al. Among authors: heitman j. Antimicrob Agents Chemother. 2001 Nov;45(11):3162-70. doi: 10.1128/AAC.45.11.3162-3170.2001. Antimicrob Agents Chemother. 2001. PMID: 11600372 Free PMC article.
588 results