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Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.
Kehlenbeck S, Betz U, Birkmann A, Fast B, Göller AH, Henninger K, Lowinger T, Marrero D, Paessens A, Paulsen D, Pevzner V, Schohe-Loop R, Tsujishita H, Welker R, Kreuter J, Rübsamen-Waigmann H, Dittmer F. Kehlenbeck S, et al. Among authors: henninger k. J Virol. 2006 Jul;80(14):6883-94. doi: 10.1128/JVI.00306-06. J Virol. 2006. PMID: 16809294 Free PMC article.
New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.
Kleymann G, Fischer R, Betz UA, Hendrix M, Bender W, Schneider U, Handke G, Eckenberg P, Hewlett G, Pevzner V, Baumeister J, Weber O, Henninger K, Keldenich J, Jensen A, Kolb J, Bach U, Popp A, Mäben J, Frappa I, Haebich D, Lockhoff O, Rübsamen-Waigmann H. Kleymann G, et al. Among authors: henninger k. Nat Med. 2002 Apr;8(4):392-8. doi: 10.1038/nm0402-392. Nat Med. 2002. PMID: 11927946
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.
Brötz-Oesterhelt H, Beyer D, Kroll HP, Endermann R, Ladel C, Schroeder W, Hinzen B, Raddatz S, Paulsen H, Henninger K, Bandow JE, Sahl HG, Labischinski H. Brötz-Oesterhelt H, et al. Among authors: henninger k. Nat Med. 2005 Oct;11(10):1082-7. doi: 10.1038/nm1306. Epub 2005 Oct 2. Nat Med. 2005. PMID: 16200071
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.
Meibom D, Wasnaire P, Beyer K, Broehl A, Cancho-Grande Y, Elowe N, Henninger K, Johannes S, Jungmann N, Krainz T, Lindner N, Maassen S, MacDonald B, Menshykau D, Mittendorf J, Sanchez G, Schaefer M, Stefan E, Torge A, Xing Y, Zubov D. Meibom D, et al. Among authors: henninger k. J Med Chem. 2024 Feb 22;67(4):2907-2940. doi: 10.1021/acs.jmedchem.3c02036. Epub 2024 Feb 13. J Med Chem. 2024. PMID: 38348661 Free PMC article.
Enantioselective Alkynylation of Unstabilized Cyclic Iminium Ions.
Guan W, Santana SO, Liao J, Henninger K, Watson MP. Guan W, et al. Among authors: henninger k. ACS Catal. 2020 Dec 4;10(23):13820-13824. doi: 10.1021/acscatal.0c04223. Epub 2020 Nov 12. ACS Catal. 2020. PMID: 38186925 Free PMC article.
18 results