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Downregulation of L-type Ca2+ channel in rat mesenteric arteries leads to loss of smooth muscle contractile phenotype and inward hypertrophic remodeling.
Kudryavtseva O, Herum KM, Dam VS, Straarup MS, Kamaev D, Briggs Boedtkjer DM, Matchkov VV, Aalkjær C. Kudryavtseva O, et al. Among authors: herum km. Am J Physiol Heart Circ Physiol. 2014 May;306(9):H1287-301. doi: 10.1152/ajpheart.00503.2013. Epub 2014 Feb 21. Am J Physiol Heart Circ Physiol. 2014. PMID: 24561864 Free article.
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart.
Romaine A, Melleby AO, Alam J, Lobert VH, Lu N, Lockwood FE, Hasic A, Lunde IG, Sjaastad I, Stenmark H, Herum KM, Gullberg D, Christensen G. Romaine A, et al. Among authors: herum km. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H1057-H1071. doi: 10.1152/ajpheart.00635.2021. Epub 2022 May 6. Am J Physiol Heart Circ Physiol. 2022. PMID: 35522553 Free article.
Overexpression of integrin α11 induces cardiac fibrosis in mice.
Romaine A, Sørensen IW, Zeltz C, Lu N, Erusappan PM, Melleby AO, Zhang L, Bendiksen B, Robinson EL, Aronsen JM, Herum KM, Danielsen HE, Sjaastad I, Christensen G, Gullberg D. Romaine A, et al. Among authors: herum km. Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12932. Epub 2017 Aug 30. Acta Physiol (Oxf). 2018. PMID: 28771943
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.
Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG. Strand ME, et al. Among authors: herum km. FEBS J. 2013 May;280(10):2228-47. doi: 10.1111/febs.12161. Epub 2013 Feb 24. FEBS J. 2013. PMID: 23374111 Free article.
Syndecans in heart fibrosis.
Lunde IG, Herum KM, Carlson CC, Christensen G. Lunde IG, et al. Among authors: herum km. Cell Tissue Res. 2016 Sep;365(3):539-52. doi: 10.1007/s00441-016-2454-2. Epub 2016 Jul 14. Cell Tissue Res. 2016. PMID: 27411689 Review.
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin.
Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G. Herum KM, et al. J Am Heart Assoc. 2020 Feb 4;9(3):e013518. doi: 10.1161/JAHA.119.013518. Epub 2020 Jan 31. J Am Heart Assoc. 2020. PMID: 32000579 Free PMC article.
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