Hewett JW - Search Results

1

The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein.

Ozelius LJ, Hewett JW, Page CE, Bressman SB, Kramer PL, Shalish C, de Leon D, Brin MF, Raymond D, Corey DP, Fahn S, Risch NJ, Buckler AJ, Gusella JF, Breakefield XO. Ozelius LJ, et al. Among authors: hewett jw. Nat Genet. 1997 Sep;17(1):40-8. doi: 10.1038/ng0997-40. Nat Genet. 1997. PMID: 9288096

2

The gene (DYT1) for early-onset torsion dystonia encodes a novel protein related to the Clp protease/heat shock family.

Ozelius LJ, Hewett JW, Page CE, Bressman SB, Kramer PL, Shalish C, de Leon D, Brin MF, Raymond D, Jacoby D, Penney J, Risch NJ, Fahn S, Gusella JF, Breakefield XO. Ozelius LJ, et al. Among authors: hewett jw. Adv Neurol. 1998;78:93-105. Adv Neurol. 1998. PMID: 9750906 Review. No abstract available.

3

The TOR1A (DYT1) gene family and its role in early onset torsion dystonia.

Ozelius LJ, Page CE, Klein C, Hewett JW, Mineta M, Leung J, Shalish C, Bressman SB, de Leon D, Brin MF, Fahn S, Corey DP, Breakefield XO. Ozelius LJ, et al. Among authors: hewett jw. Genomics. 1999 Dec 15;62(3):377-84. doi: 10.1006/geno.1999.6039. Genomics. 1999. PMID: 10644435

4

The DYT1 gene on 9q34 is responsible for most cases of early limb-onset idiopathic torsion dystonia in non-Jews.

Kramer PL, Heiman GA, Gasser T, Ozelius LJ, de Leon D, Brin MF, Burke RE, Hewett J, Hunt AL, Moskowitz C, et al. Kramer PL, et al. Am J Hum Genet. 1994 Sep;55(3):468-75. Am J Hum Genet. 1994. PMID: 8079990 Free PMC article.

5

Fine localization of the torsion dystonia gene (DYT1) on human chromosome 9q34: YAC map and linkage disequilibrium.

Ozelius LJ, Hewett J, Kramer P, Bressman SB, Shalish C, de Leon D, Rutter M, Risch N, Brin MF, Markova ED, Limborska SA, Ivanova-Smolenskaya IA, McCormick MK, Fahn S, Buckler AJ, Gusella JF, Breakefield XO. Ozelius LJ, et al. Genome Res. 1997 May;7(5):483-94. doi: 10.1101/gr.7.5.483. Genome Res. 1997. PMID: 9149944 Free article.

6

Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.

Hewett J, Gonzalez-Agosti C, Slater D, Ziefer P, Li S, Bergeron D, Jacoby DJ, Ozelius LJ, Ramesh V, Breakefield XO. Hewett J, et al. Hum Mol Genet. 2000 May 22;9(9):1403-13. doi: 10.1093/hmg/9.9.1403. Hum Mol Genet. 2000. PMID: 10814722

7

TorsinA protein and neuropathology in early onset generalized dystonia with GAG deletion.

Rostasy K, Augood SJ, Hewett JW, Leung JC, Sasaki H, Ozelius LJ, Ramesh V, Standaert DG, Breakefield XO, Hedreen JC. Rostasy K, et al. Among authors: hewett jw. Neurobiol Dis. 2003 Feb;12(1):11-24. doi: 10.1016/s0969-9961(02)00010-4. Neurobiol Dis. 2003. PMID: 12609485

8

Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics.

Hewett JW, Zeng J, Niland BP, Bragg DC, Breakefield XO. Hewett JW, et al. Neurobiol Dis. 2006 Apr;22(1):98-111. doi: 10.1016/j.nbd.2005.10.012. Epub 2005 Dec 19. Neurobiol Dis. 2006. PMID: 16361107

9

Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells.

Hewett JW, Tannous B, Niland BP, Nery FC, Zeng J, Li Y, Breakefield XO. Hewett JW, et al. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7271-6. doi: 10.1073/pnas.0701185104. Epub 2007 Apr 11. Proc Natl Acad Sci U S A. 2007. PMID: 17428918 Free PMC article.

10

siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells.

Hewett JW, Nery FC, Niland B, Ge P, Tan P, Hadwiger P, Tannous BA, Sah DW, Breakefield XO. Hewett JW, et al. Hum Mol Genet. 2008 May 15;17(10):1436-45. doi: 10.1093/hmg/ddn032. Epub 2008 Feb 7. Hum Mol Genet. 2008. PMID: 18258738 Free PMC article.

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