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Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.
Goris A, Pauwels I, Gustavsen MW, van Son B, Hilven K, Bos SD, Celius EG, Berg-Hansen P, Aarseth J, Myhr KM, D'Alfonso S, Barizzone N, Leone MA, Martinelli Boneschi F, Sorosina M, Liberatore G, Kockum I, Olsson T, Hillert J, Alfredsson L, Bedri SK, Hemmer B, Buck D, Berthele A, Knier B, Biberacher V, van Pesch V, Sindic C, Bang Oturai A, Søndergaard HB, Sellebjerg F, Jensen PE, Comabella M, Montalban X, Pérez-Boza J, Malhotra S, Lechner-Scott J, Broadley S, Slee M, Taylor B, Kermode AG, Gourraud PA; International Multiple Sclerosis Genetics Consortium; Sawcer SJ, Andreassen BK, Dubois B, Harbo HF. Goris A, et al. Among authors: hilven k. Brain. 2015 Mar;138(Pt 3):632-43. doi: 10.1093/brain/awu405. Epub 2015 Jan 22. Brain. 2015. PMID: 25616667 Free PMC article.
No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis.
Barizzone N, Pauwels I, Luciano B, Franckaert D, Guerini FR, Cosemans L, Hilven K, Salviati A, Dooley J, Danso-Abeam D, di Sapio A, Cavalla P, Decallonne B, Mathieu C, Liston A, Leone M, Dubois B, D'Alfonso S, Goris A. Barizzone N, et al. Among authors: hilven k. Ann Neurol. 2013 Mar;73(3):433-7. doi: 10.1002/ana.23834. Epub 2013 Mar 11. Ann Neurol. 2013. PMID: 23483640
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.
Sadovnick AD, Traboulsee AL, Bernales CQ, Ross JP, Forwell AL, Yee IM, Guillot-Noel L, Fontaine B, Cournu-Rebeix I, Alcina A, Fedetz M, Izquierdo G, Matesanz F, Hilven K, Dubois B, Goris A, Astobiza I, Alloza I, Antigüedad A, Vandenbroeck K, Akkad DA, Aktas O, Blaschke P, Buttmann M, Chan A, Epplen JT, Gerdes LA, Kroner A, Kubisch C, Kümpfel T, Lohse P, Rieckmann P, Zettl UK, Zipp F, Bertram L, Lill CM, Fernandez O, Urbaneja P, Leyva L, Alvarez-Cermeño JC, Arroyo R, Garagorri AM, García-Martínez A, Villar LM, Urcelay E, Malhotra S, Montalban X, Comabella M, Berger T, Fazekas F, Reindl M, Schmied MC, Zimprich A, Vilariño-Güell C. Sadovnick AD, et al. Among authors: hilven k. G3 (Bethesda). 2016 Jul 7;6(7):2073-9. doi: 10.1534/g3.116.030841. G3 (Bethesda). 2016. PMID: 27194806 Free PMC article.
Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations.
Dooley J, Pauwels I, Franckaert D, Smets I, Garcia-Perez JE, Hilven K, Danso-Abeam D, Terbeek J, Nguyen AT, De Muynck L, Decallonne B, Dubois B, Liston A, Goris A. Dooley J, et al. Among authors: hilven k. Neurol Neuroimmunol Neuroinflamm. 2016 May 10;3(4):e240. doi: 10.1212/NXI.0000000000000240. eCollection 2016 Aug. Neurol Neuroimmunol Neuroinflamm. 2016. PMID: 27231713 Free PMC article.
A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease.
Van Horebeek L, Hilven K, Mallants K, Van Nieuwenhuijze A, Kelkka T, Savola P, Mustjoki S, Schlenner SM, Liston A, Dubois B, Goris A. Van Horebeek L, et al. Among authors: hilven k. Hum Mol Genet. 2019 Apr 15;28(8):1369-1380. doi: 10.1093/hmg/ddy425. Hum Mol Genet. 2019. PMID: 30541027 Free PMC article.
Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.
Lagou V, Garcia-Perez JE, Smets I, Van Horebeek L, Vandebergh M, Chen L, Mallants K, Prezzemolo T, Hilven K, Humblet-Baron S, Moisse M, Van Damme P, Boeckxstaens G, Bowness P, Dubois B, Dooley J, Liston A, Goris A. Lagou V, et al. Among authors: hilven k. Cell Rep. 2018 Oct 16;25(3):798-810.e6. doi: 10.1016/j.celrep.2018.09.048. Cell Rep. 2018. PMID: 30332657 Free PMC article.
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