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Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.
García-Lerma JG, Cong ME, Mitchell J, Youngpairoj AS, Zheng Q, Masciotra S, Martin A, Kuklenyik Z, Holder A, Lipscomb J, Pau CP, Barr JR, Hanson DL, Otten R, Paxton L, Folks TM, Heneine W. García-Lerma JG, et al. Among authors: holder a. Sci Transl Med. 2010 Jan 13;2(14):14ra4. doi: 10.1126/scitranslmed.3000391. Sci Transl Med. 2010. PMID: 20371467
Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors.
García-Lerma JG, Aung W, Cong ME, Zheng Q, Youngpairoj AS, Mitchell J, Holder A, Martin A, Kuklenyik S, Luo W, Lin CY, Hanson DL, Kersh E, Pau CP, Ray AS, Rooney JF, Lee WA, Heneine W. García-Lerma JG, et al. Among authors: holder a. J Virol. 2011 Jul;85(13):6610-7. doi: 10.1128/JVI.00311-11. Epub 2011 Apr 27. J Virol. 2011. PMID: 21525346 Free PMC article.
Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques.
Moss JA, Malone AM, Smith TJ, Butkyavichene I, Cortez C, Gilman J, Kennedy S, Kopin E, Nguyen C, Sinha P, Hendry RM, Guenthner P, Holder A, Martin A, McNicholl J, Mitchell J, Pau CP, Srinivasan P, Smith JM, Baum MM. Moss JA, et al. Among authors: holder a. Antimicrob Agents Chemother. 2012 Nov;56(11):5952-60. doi: 10.1128/AAC.01198-12. Epub 2012 Sep 10. Antimicrob Agents Chemother. 2012. PMID: 22964245 Free PMC article.
Effects of gel volume on pharmacokinetics for vaginal and rectal applications of combination DuoGel-IQB4012, a dual chamber-dual drug HIV microbicide gel, in pigtailed macaques.
Pereira LE, Singletary T, Martin A, Dinh CT, Deyounks F, Holder A, McNicholl J, Buckheit KW, Buckheit RW Jr, Ham A, Katz DF, Smith JM. Pereira LE, et al. Among authors: holder a. Drug Deliv Transl Res. 2018 Oct;8(5):1180-1190. doi: 10.1007/s13346-018-0538-0. Drug Deliv Transl Res. 2018. PMID: 29761350 Free PMC article.
Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaques.
Makarova N, Singletary T, Peet MM, Mitchell J, Holder A, Dinh C, Agrahari V, Mendoza M, Pan Y, Heneine W, Clark MR, García-Lerma JG, Smith JM, Doncel GF. Makarova N, et al. Among authors: holder a. EBioMedicine. 2022 Dec;86:104338. doi: 10.1016/j.ebiom.2022.104338. Epub 2022 Nov 5. EBioMedicine. 2022. PMID: 36343572 Free PMC article.
Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques.
Dobard CW, Peet MM, Nishiura K, Holder A, Dinh C, Mitchell J, Khalil G, Pan Y, Singh ON, McCormick TJ, Agrahari V, Gupta P, Jonnalagadda S, Heneine W, Clark MR, García-Lerma JG, Doncel GF. Dobard CW, et al. Among authors: holder a. EBioMedicine. 2022 Dec;86:104361. doi: 10.1016/j.ebiom.2022.104361. Epub 2022 Nov 21. EBioMedicine. 2022. PMID: 36423375 Free PMC article.
Extended post-exposure protection against vaginal SHIV infection with tenofovir alafenamide fumarate/elvitegravir inserts in macaques.
Makarova N, Singletary T, Peet MM, Mitchell J, Bachman S, Holder A, Dinh C, Lipscomb J, Agrahari V, Mendoza M, Pan Y, Heneine W, Clark MR, García-Lerma JG, Doncel GF, Smith JM. Makarova N, et al. Among authors: holder a. J Infect Dis. 2023 Dec 22:jiad599. doi: 10.1093/infdis/jiad599. Online ahead of print. J Infect Dis. 2023. PMID: 38134382
848 results