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Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.
Luci DK, Jameson JB 2nd, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ. Luci DK, et al. Among authors: holinstat m. J Med Chem. 2014 Jan 23;57(2):495-506. doi: 10.1021/jm4016476. Epub 2014 Jan 6. J Med Chem. 2014. PMID: 24393039 Free PMC article.
Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets.
Larsen HJ, Byrne D, Özpolat T, Chauhan A, Bailey SL, Rhoads N, Reed F, Stolla MC, Adili R, Holinstat M, Fu X, Stolla M. Larsen HJ, et al. Among authors: holinstat m. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1990-2007. doi: 10.1161/ATVBAHA.123.319021. Epub 2023 Aug 31. Arterioscler Thromb Vasc Biol. 2023. PMID: 37650322
Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design.
La CC, Smith SA, Vappala S, Adili R, Luke CE, Abbina S, Luo HD, Chafeeva I, Drayton M, Creagh LA, de Guadalupe Jaraquemada-Peláez M, Rhoads N, Kalathottukaren MT, Henke PK, Straus SK, Du C, Conway EM, Holinstat M, Haynes CA, Morrissey JH, Kizhakkedathu JN. La CC, et al. Among authors: holinstat m. Nat Commun. 2023 Apr 26;14(1):2177. doi: 10.1038/s41467-023-37709-0. Nat Commun. 2023. PMID: 37100783 Free PMC article.
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Kenyon V, et al. Among authors: holinstat m. J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739938 Free PMC article.
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.
Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Yeung J, et al. Among authors: holinstat m. Mol Pharmacol. 2012 Mar;81(3):420-30. doi: 10.1124/mol.111.075630. Epub 2011 Dec 9. Mol Pharmacol. 2012. PMID: 22155783 Free PMC article.
Newer agents in antiplatelet therapy: a review.
Yeung J, Holinstat M. Yeung J, et al. Among authors: holinstat m. J Blood Med. 2012;3:33-42. doi: 10.2147/JBM.S25421. Epub 2012 Jun 25. J Blood Med. 2012. PMID: 22792011 Free PMC article.
106 results