Holman TR - Search Results

1

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Kenyon V, et al. Among authors: holman tr. J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739938 Free PMC article.

2

Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.

Whitman S, Gezginci M, Timmermann BN, Holman TR. Whitman S, et al. Among authors: holman tr. J Med Chem. 2002 Jun 6;45(12):2659-61. doi: 10.1021/jm0201262. J Med Chem. 2002. PMID: 12036375

3

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Segraves EN, et al. Among authors: holman tr. J Med Chem. 2004 Jul 29;47(16):4060-5. doi: 10.1021/jm049872s. J Med Chem. 2004. PMID: 15267244

4

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Cichewicz RH, et al. Among authors: holman tr. J Am Chem Soc. 2004 Nov 17;126(45):14910-20. doi: 10.1021/ja046082z. J Am Chem Soc. 2004. PMID: 15535718

5

Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis.

Cichewicz RH, Clifford LJ, Lassen PR, Cao X, Freedman TB, Nafie LA, Deschamps JD, Kenyon VA, Flanary JR, Holman TR, Crews P. Cichewicz RH, et al. Among authors: holman tr. Bioorg Med Chem. 2005 Oct 1;13(19):5600-12. doi: 10.1016/j.bmc.2005.06.020. Bioorg Med Chem. 2005. PMID: 16039133

6

Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.

Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP. Kenyon V, et al. Among authors: holman tr. J Med Chem. 2006 Feb 23;49(4):1356-63. doi: 10.1021/jm050639j. J Med Chem. 2006. PMID: 16480270

7

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

Deschamps JD, Kenyon VA, Holman TR. Deschamps JD, et al. Among authors: holman tr. Bioorg Med Chem. 2006 Jun 15;14(12):4295-301. doi: 10.1016/j.bmc.2006.01.057. Epub 2006 Feb 24. Bioorg Med Chem. 2006. PMID: 16500106

8

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR. Deschamps JD, et al. Among authors: holman tr. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. doi: 10.1016/j.bmc.2007.08.015. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17826100 Free PMC article.

9

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Vasquez-Martinez Y, Ohri RV, Kenyon V, Holman TR, Sepúlveda-Boza S. Vasquez-Martinez Y, et al. Among authors: holman tr. Bioorg Med Chem. 2007 Dec 1;15(23):7408-25. doi: 10.1016/j.bmc.2007.07.036. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17869117 Free PMC article.

10

Novel lipoxygenase inhibitors as neuroprotective reagents.

van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. van Leyen K, et al. Among authors: holman tr. J Neurosci Res. 2008 Mar;86(4):904-9. doi: 10.1002/jnr.21543. J Neurosci Res. 2008. PMID: 17960827 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

108 results

Search Page