Holman TR - Search Results

1

Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.

Dobrian AD, Morris MA, Taylor-Fishwick DA, Holman TR, Imai Y, Mirmira RG, Nadler JL. Dobrian AD, et al. Among authors: holman tr. Pharmacol Ther. 2019 Mar;195:100-110. doi: 10.1016/j.pharmthera.2018.10.010. Epub 2018 Oct 19. Pharmacol Ther. 2019. PMID: 30347209 Free PMC article. Review.

2

Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.

Mogul R, Johansen E, Holman TR. Mogul R, et al. Among authors: holman tr. Biochemistry. 2000 Apr 25;39(16):4801-7. doi: 10.1021/bi992805t. Biochemistry. 2000. PMID: 10769137

3

Stopped-flow kinetic investigations of the activation of soybean lipoxygenase-1 and the influence of inhibitors on the allosteric site.

Ruddat VC, Whitman S, Holman TR, Bernasconi CF. Ruddat VC, et al. Among authors: holman tr. Biochemistry. 2003 Apr 15;42(14):4172-8. doi: 10.1021/bi020698o. Biochemistry. 2003. PMID: 12680771

4

Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.

Segraves EN, Holman TR. Segraves EN, et al. Among authors: holman tr. Biochemistry. 2003 May 13;42(18):5236-43. doi: 10.1021/bi0273462. Biochemistry. 2003. PMID: 12731864

5

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Cichewicz RH, et al. Among authors: holman tr. J Am Chem Soc. 2004 Nov 17;126(45):14910-20. doi: 10.1021/ja046082z. J Am Chem Soc. 2004. PMID: 15535718

6

Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.

Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP. Kenyon V, et al. Among authors: holman tr. J Med Chem. 2006 Feb 23;49(4):1356-63. doi: 10.1021/jm050639j. J Med Chem. 2006. PMID: 16480270

7

Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.

Wecksler AT, Kenyon V, Garcia NK, Deschamps JD, van der Donk WA, Holman TR. Wecksler AT, et al. Among authors: holman tr. Biochemistry. 2009 Sep 15;48(36):8721-30. doi: 10.1021/bi9009242. Biochemistry. 2009. PMID: 19645454 Free PMC article.

8

Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1.

Wecksler AT, Garcia NK, Holman TR. Wecksler AT, et al. Among authors: holman tr. Bioorg Med Chem. 2009 Sep 15;17(18):6534-9. doi: 10.1016/j.bmc.2009.08.005. Epub 2009 Aug 8. Bioorg Med Chem. 2009. PMID: 19716306 Free PMC article.

9

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Kenyon V, et al. Among authors: holman tr. J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739938 Free PMC article.

10

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.

Weaver JR, Holman TR, Imai Y, Jadhav A, Kenyon V, Maloney DJ, Nadler JL, Rai G, Simeonov A, Taylor-Fishwick DA. Weaver JR, et al. Among authors: holman tr. Mol Cell Endocrinol. 2012 Jul 6;358(1):88-95. doi: 10.1016/j.mce.2012.03.004. Epub 2012 Mar 20. Mol Cell Endocrinol. 2012. PMID: 22502743

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