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Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.
Mathijssen NC, Masereeuw R, Holme PA, van Kraaij MG, Laros-van Gorkom BA, Peyvandi F, van Heerde WL. Mathijssen NC, et al. Among authors: holme pa. Thromb Res. 2013 Aug;132(2):256-62. doi: 10.1016/j.thromres.2013.05.027. Epub 2013 Jul 6. Thromb Res. 2013. PMID: 23834817 Free article. Clinical Trial.
Current view and outcome of ITI therapy - A change over time?
Holstein K, Batorova A, Carvalho M, Fijnvandraat K, Holme P, Kavakli K, Lambert T, Rocino A, Jiménez-Yuste V, Astermark J; European Haemophilia Therapy Strategy Board (EHTSB). Holstein K, et al. Thromb Res. 2016 Dec;148:38-44. doi: 10.1016/j.thromres.2016.10.015. Epub 2016 Oct 15. Thromb Res. 2016. PMID: 27770665
New Inhibitors in the Ageing Population: A Retrospective, Observational, Cohort Study of New Inhibitors in Older People with Hemophilia.
Astermark J, Ay C, Carvalho M, D'Oiron R, Moerloose P, Dolan G, Fontana P, Hermans C, Holme PA, Katsarou O, Kenet G, Klamroth R, Mancuso ME, Marquardt N, Núñez R, Pabinger I, Tait R, Valk PV. Astermark J, et al. Among authors: holme pa. Thromb Haemost. 2022 Jun;122(6):905-912. doi: 10.1055/a-1642-4067. Epub 2021 Nov 5. Thromb Haemost. 2022. PMID: 34507368
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