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225 results

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Page 1
The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.
He S, Ye Z, Truong Q, Shah S, Du W, Guo L, Dobbelaar PH, Lai Z, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Pasternak A, Feng Z, deJesus R, Yang L, Reibarkh M, Bradley SA, Holmes MA, Ball RG, Ruck RT, Huffman MA, Wong F, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Eiermann GJ, Li C, Zhang BB, Howard AD, Zhou YP, Nargund RP, Hagmann WK. He S, et al. Among authors: holmes ma. ACS Med Chem Lett. 2012 May 7;3(6):484-9. doi: 10.1021/ml300063m. eCollection 2012 Jun 14. ACS Med Chem Lett. 2012. PMID: 24900499 Free PMC article.
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
He S, Ye Z, Dobbelaar PH, Bakshi RK, Hong Q, Dellureficio JP, Sebhat IK, Guo L, Liu J, Jian T, Lai Y, Franklin CL, Reibarkh M, Holmes MA, Weinberg DH, MacNeil T, Tang R, Tamvakopoulos C, Peng Q, Miller RR, Stearns RA, Chen HY, Chen AS, Strack AM, Fong TM, Wyvratt MJ Jr, Nargund RP. He S, et al. Among authors: holmes ma. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6524-32. doi: 10.1016/j.bmcl.2010.09.049. Epub 2010 Sep 19. Bioorg Med Chem Lett. 2010. PMID: 20933410
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Armstrong HM, Wong F, Holmes MA, Sinclair PJ, Goulet MT, Dumont FJ, Staruch MJ, Koprak S, Peterson LB, Rosa R, Wilusz MB, Wiederrecht GJ, Cryan JG, Wyvratt MJ, Parsons WH. Armstrong HM, et al. Among authors: holmes ma. Bioorg Med Chem Lett. 1999 Jul 19;9(14):2089-94. doi: 10.1016/s0960-894x(99)00336-4. Bioorg Med Chem Lett. 1999. PMID: 10450987
Disubstituted pyrimidines as Lck inhibitors.
Hunt JA, Beresis RT, Goulet JL, Holmes MA, Hong XJ, Kovacs E, Mills SG, Ruzek RD, Wong F, Hermes JD, Park YW, Salowe SP, Sonatore LM, Wu L, Woods A, Zaller DM, Sinclair PJ. Hunt JA, et al. Among authors: holmes ma. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5440-3. doi: 10.1016/j.bmcl.2009.07.102. Epub 2009 Jul 25. Bioorg Med Chem Lett. 2009. PMID: 19674899
Androstenediol analogs as ER-beta-selective SERMs.
Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Sharma N, Fitzgerald PM, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: holmes ma. Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. doi: 10.1016/j.bmcl.2005.11.014. Epub 2005 Nov 23. Bioorg Med Chem Lett. 2006. PMID: 16309907
Bridged androstenediol analogs as ER-beta selective SERMs.
Blizzard TA, Gude C, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Holmes MA, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: holmes ma. Bioorg Med Chem Lett. 2007 May 15;17(10):2944-8. doi: 10.1016/j.bmcl.2006.12.053. Epub 2006 Dec 21. Bioorg Med Chem Lett. 2007. PMID: 17448656
Androstene-3,5-dienes as ER-beta selective SERMs.
Blizzard TA, Gude C, Morgan JD 2nd, Chan W, Birzin ET, Mojena M, Tudela C, Chen F, Knecht K, Su Q, Kraker B, Mosley RT, Holmes MA, Rohrer SP, Hammond ML. Blizzard TA, et al. Among authors: holmes ma. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6295-8. doi: 10.1016/j.bmcl.2007.09.001. Epub 2007 Sep 7. Bioorg Med Chem Lett. 2007. PMID: 17890084
Trade-offs in the externalities of pig production are not inevitable.
Bartlett H, Zanella M, Kaori B, Sabei L, Araujo MS, de Paula TM, Zanella AJ, Holmes MA, Wood JLN, Balmford A. Bartlett H, et al. Among authors: holmes ma. Nat Food. 2024 Apr;5(4):312-322. doi: 10.1038/s43016-024-00921-2. Epub 2024 Apr 11. Nat Food. 2024. PMID: 38605128 Free PMC article.
Antibiotic resistance determination using Enterococcus faecium whole-genome sequences: a diagnostic accuracy study using genotypic and phenotypic data.
Coll F, Gouliouris T, Blane B, Yeats CA, Raven KE, Ludden C, Khokhar FA, Wilson HJ, Roberts LW, Harrison EM, Horner CS, Le TH, Nguyen TH, Nguyen VT, Brown NM, Holmes MA, Parkhill J, Estee Török M, Peacock SJ. Coll F, et al. Among authors: holmes ma. Lancet Microbe. 2024 Feb;5(2):e151-e163. doi: 10.1016/S2666-5247(23)00297-5. Epub 2024 Jan 11. Lancet Microbe. 2024. PMID: 38219758 Free article.
225 results