Hommel U - Search Results

1

Correct folding of circularly permuted variants of a beta alpha barrel enzyme in vivo.

Luger K, Hommel U, Herold M, Hofsteenge J, Kirschner K. Luger K, et al. Among authors: hommel u. Science. 1989 Jan 13;243(4888):206-10. doi: 10.1126/science.2643160. Science. 1989. PMID: 2643160

2

Purification and characterization of yeast anthranilate phosphoribosyltransferase.

Hommel U, Lustig A, Kirschner K. Hommel U, et al. Eur J Biochem. 1989 Mar 1;180(1):33-40. doi: 10.1111/j.1432-1033.1989.tb14611.x. Eur J Biochem. 1989. PMID: 2651124 Free article.

3

Indoleglycerol phosphate synthase-phosphoribosyl anthranilate isomerase: comparison of the bifunctional enzyme from Escherichia coli with engineered monofunctional domains.

Eberhard M, Tsai-Pflugfelder M, Bolewska K, Hommel U, Kirschner K. Eberhard M, et al. Among authors: hommel u. Biochemistry. 1995 Apr 25;34(16):5419-28. doi: 10.1021/bi00016a013. Biochemistry. 1995. PMID: 7727400

4

Phosphoribosyl anthranilate isomerase catalyzes a reversible amadori reaction.

Hommel U, Eberhard M, Kirschner K. Hommel U, et al. Biochemistry. 1995 Apr 25;34(16):5429-39. doi: 10.1021/bi00016a014. Biochemistry. 1995. PMID: 7727401

5

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.

Ostermann N, Eder J, Eidhoff U, Zink F, Hassiepen U, Worpenberg S, Maibaum J, Simic O, Hommel U, Gerhartz B. Ostermann N, et al. Among authors: hommel u. J Mol Biol. 2006 Jan 13;355(2):249-61. doi: 10.1016/j.jmb.2005.10.027. Epub 2005 Nov 8. J Mol Biol. 2006. PMID: 16305800

6

Solution structure of a cysteine rich domain of rat protein kinase C.

Hommel U, Zurini M, Luyten M. Hommel U, et al. Nat Struct Biol. 1994 Jun;1(6):383-7. doi: 10.1038/nsb0694-383. Nat Struct Biol. 1994. PMID: 7664052

7

Aspartic proteases in drug discovery.

Eder J, Hommel U, Cumin F, Martoglio B, Gerhartz B. Eder J, et al. Among authors: hommel u. Curr Pharm Des. 2007;13(3):271-85. doi: 10.2174/138161207779313560. Curr Pharm Des. 2007. PMID: 17313361 Review.

8

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Mac Sweeney A, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K. Maibaum J, et al. Among authors: hommel u. Nat Chem Biol. 2016 Dec;12(12):1105-1110. doi: 10.1038/nchembio.2208. Epub 2016 Oct 24. Nat Chem Biol. 2016. PMID: 27775713

9

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

Vulpetti A, Randl S, Rüdisser S, Ostermann N, Erbel P, Mac Sweeney A, Zoller T, Salem B, Gerhartz B, Cumin F, Hommel U, Dalvit C, Lorthiois E, Maibaum J. Vulpetti A, et al. Among authors: hommel u. J Med Chem. 2017 Mar 9;60(5):1946-1958. doi: 10.1021/acs.jmedchem.6b01684. Epub 2017 Feb 20. J Med Chem. 2017. PMID: 28157311

10

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.

Lorthiois E, Anderson K, Vulpetti A, Rogel O, Cumin F, Ostermann N, Steinbacher S, Mac Sweeney A, Delgado O, Liao SM, Randl S, Rüdisser S, Dussauge S, Fettis K, Kieffer L, de Erkenez A, Yang L, Hartwieg C, Argikar UA, La Bonte LR, Newton R, Kansara V, Flohr S, Hommel U, Jaffee B, Maibaum J. Lorthiois E, et al. Among authors: hommel u. J Med Chem. 2017 Jul 13;60(13):5717-5735. doi: 10.1021/acs.jmedchem.7b00425. Epub 2017 Jun 30. J Med Chem. 2017. PMID: 28621538

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