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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. Franklin BS, et al. Among authors: hornemann s. Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22. Nat Immunol. 2014. PMID: 24952505 Free PMC article.
Prion strain discrimination using luminescent conjugated polymers.
Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. Sigurdson CJ, et al. Among authors: hornemann s. Nat Methods. 2007 Dec;4(12):1023-30. doi: 10.1038/nmeth1131. Epub 2007 Nov 18. Nat Methods. 2007. PMID: 18026110
De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis.
Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. Sigurdson CJ, et al. Among authors: hornemann s. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):304-9. doi: 10.1073/pnas.0810680105. Epub 2008 Dec 10. Proc Natl Acad Sci U S A. 2009. PMID: 19073920 Free PMC article.
The amyloid-Congo red interface at atomic resolution.
Schütz AK, Soragni A, Hornemann S, Aguzzi A, Ernst M, Böckmann A, Meier BH. Schütz AK, et al. Among authors: hornemann s. Angew Chem Int Ed Engl. 2011 Jun 20;50(26):5956-60. doi: 10.1002/anie.201008276. Epub 2011 May 17. Angew Chem Int Ed Engl. 2011. PMID: 21591034 No abstract available.
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, Liberski PP, James MN, Aguzzi A. Sonati T, et al. Among authors: hornemann s. Nature. 2013 Sep 5;501(7465):102-6. doi: 10.1038/nature12402. Epub 2013 Jul 31. Nature. 2013. PMID: 23903654 Free article.
Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.
Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A. Herrmann US, et al. Among authors: hornemann s. PLoS Pathog. 2015 Feb 24;11(2):e1004662. doi: 10.1371/journal.ppat.1004662. eCollection 2015 Feb. PLoS Pathog. 2015. PMID: 25710374 Free PMC article.
Differential Toxicity of Antibodies to the Prion Protein.
Reimann RR, Sonati T, Hornemann S, Herrmann US, Arand M, Hawke S, Aguzzi A. Reimann RR, et al. Among authors: hornemann s. PLoS Pathog. 2016 Jan 28;12(1):e1005401. doi: 10.1371/journal.ppat.1005401. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26821311 Free PMC article.
Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication.
Frontzek K, Pfammatter M, Sorce S, Senatore A, Schwarz P, Moos R, Frauenknecht K, Hornemann S, Aguzzi A. Frontzek K, et al. Among authors: hornemann s. PLoS One. 2016 Sep 29;11(9):e0163601. doi: 10.1371/journal.pone.0163601. eCollection 2016. PLoS One. 2016. PMID: 27684562 Free PMC article.
104 results