Hu K - Search Results

1

Overcoming resistance to Sonic Hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma.

Pambid MR, Berns R, Adomat HH, Hu K, Triscott J, Maurer N, Zisman N, Ramaswamy V, Hawkins CE, Taylor MD, Dunham C, Guns E, Dunn SE. Pambid MR, et al. Among authors: hu k. Pediatr Blood Cancer. 2014 Jan;61(1):107-15. doi: 10.1002/pbc.24675. Epub 2013 Aug 12. Pediatr Blood Cancer. 2014. PMID: 23940083

2

Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice.

Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, Dunn SE. Lee C, et al. Among authors: hu k. Cancer Res. 2008 Nov 1;68(21):8661-6. doi: 10.1158/0008-5472.CAN-08-1082. Cancer Res. 2008. PMID: 18974106

3

Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.

Hu K, Lee C, Qiu D, Fotovati A, Davies A, Abu-Ali S, Wai D, Lawlor ER, Triche TJ, Pallen CJ, Dunn SE. Hu K, et al. Mol Cancer Ther. 2009 Nov;8(11):3024-35. doi: 10.1158/1535-7163.MCT-09-0365. Epub 2009 Nov 3. Mol Cancer Ther. 2009. PMID: 19887553 Free PMC article.

4

Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells.

Hu K, Law JH, Fotovati A, Dunn SE. Hu K, et al. Breast Cancer Res. 2012 Feb 6;14(1):R22. doi: 10.1186/bcr3107. Breast Cancer Res. 2012. PMID: 22309939 Free PMC article.

5

Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.

Stratford AL, Reipas K, Hu K, Fotovati A, Brough R, Frankum J, Takhar M, Watson P, Ashworth A, Lord CJ, Lasham A, Print CG, Dunn SE. Stratford AL, et al. Among authors: hu k. Stem Cells. 2012 Jul;30(7):1338-48. doi: 10.1002/stem.1128. Stem Cells. 2012. PMID: 22674792

6

Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.

Triscott J, Lee C, Hu K, Fotovati A, Berns R, Pambid M, Luk M, Kast RE, Kong E, Toyota E, Yip S, Toyota B, Dunn SE. Triscott J, et al. Among authors: hu k. Oncotarget. 2012 Oct;3(10):1112-23. doi: 10.18632/oncotarget.604. Oncotarget. 2012. PMID: 23047041 Free PMC article.

7

Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells.

Davies AH, Reipas K, Hu K, Berns R, Firmino N, Stratford AL, Dunn SE. Davies AH, et al. Among authors: hu k. Oncotarget. 2015 Aug 21;6(24):20570-7. doi: 10.18632/oncotarget.4135. Oncotarget. 2015. PMID: 26011941 Free PMC article.

8

Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

Law JH, Habibi G, Hu K, Masoudi H, Wang MY, Stratford AL, Park E, Gee JM, Finlay P, Jones HE, Nicholson RI, Carboni J, Gottardis M, Pollak M, Dunn SE. Law JH, et al. Among authors: hu k. Cancer Res. 2008 Dec 15;68(24):10238-46. doi: 10.1158/0008-5472.CAN-08-2755. Cancer Res. 2008. PMID: 19074892

9

Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance.

To K, Fotovati A, Reipas KM, Law JH, Hu K, Wang J, Astanehe A, Davies AH, Lee L, Stratford AL, Raouf A, Johnson P, Berquin IM, Royer HD, Eaves CJ, Dunn SE. To K, et al. Among authors: hu k. Cancer Res. 2010 Apr 1;70(7):2840-51. doi: 10.1158/0008-5472.CAN-09-3155. Epub 2010 Mar 23. Cancer Res. 2010. PMID: 20332234 Free PMC article.

10

YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.

Davies AH, Reipas KM, Pambid MR, Berns R, Stratford AL, Fotovati A, Firmino N, Astanehe A, Hu K, Maxwell C, Mills GB, Dunn SE. Davies AH, et al. Among authors: hu k. Stem Cells. 2014 Jun;32(6):1437-50. doi: 10.1002/stem.1707. Stem Cells. 2014. PMID: 24648416 Free PMC article.

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