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Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.
Ables GP, Yang KJ, Vogel S, Hernandez-Ono A, Yu S, Yuen JJ, Birtles S, Buckett LK, Turnbull AV, Goldberg IJ, Blaner WS, Huang LS, Ginsberg HN. Ables GP, et al. Among authors: huang ls. J Lipid Res. 2012 Nov;53(11):2364-79. doi: 10.1194/jlr.M029041. Epub 2012 Aug 21. J Lipid Res. 2012. PMID: 22911105 Free PMC article.
Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.
Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV Jr, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ. Liu L, et al. Among authors: huang ls. J Biol Chem. 2014 Oct 24;289(43):29881-91. doi: 10.1074/jbc.M114.601864. Epub 2014 Aug 25. J Biol Chem. 2014. PMID: 25157099 Free PMC article.
Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice.
Son NH, Park TS, Yamashita H, Yokoyama M, Huggins LA, Okajima K, Homma S, Szabolcs MJ, Huang LS, Goldberg IJ. Son NH, et al. Among authors: huang ls. J Clin Invest. 2007 Oct;117(10):2791-801. doi: 10.1172/JCI30335. J Clin Invest. 2007. PMID: 17823655 Free PMC article.
Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis.
Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, Goldberg IJ, Schwabe RF, Chua SC Jr, Huang LS. Reid BN, et al. Among authors: huang ls. J Biol Chem. 2008 May 9;283(19):13087-99. doi: 10.1074/jbc.M800533200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18337240 Free PMC article.
435 results