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1932 1
1945 3
1946 19
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1948 28
1949 18
1950 106
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1952 298
1953 185
1954 94
1955 148
1956 105
1957 111
1958 87
1959 96
1960 78
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1962 86
1963 146
1964 151
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1966 124
1967 108
1968 93
1969 120
1970 114
1971 99
1972 91
1973 123
1974 138
1975 151
1976 157
1977 147
1978 170
1979 182
1980 198
1981 238
1982 217
1983 235
1984 316
1985 284
1986 272
1987 1088
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1990 3265
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1994 3742
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1996 3843
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1998 4047
1999 4192
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2011 12639
2012 13671
2013 16001
2014 21286
2015 24743
2016 26163
2017 27337
2018 28482
2019 29247
2020 33379
2021 36513
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2023 31291
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431,130 results

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Page 1
Showing results for human md
Search for Humayun MD instead (2 results)
Pan-genomics in the human genome era.
Sherman RM, Salzberg SL. Sherman RM, et al. Nat Rev Genet. 2020 Apr;21(4):243-254. doi: 10.1038/s41576-020-0210-7. Epub 2020 Feb 7. Nat Rev Genet. 2020. PMID: 32034321 Free PMC article. Review.
Here we review efforts to create pan-genomes for a range of species, from bacteria to humans, and we further consider the computational methods that have been proposed in order to capture, interpret and compare pan-genome data. As scientists continue to survey and catalogu …
Here we review efforts to create pan-genomes for a range of species, from bacteria to humans, and we further consider the computation …
Transposable elements in human genetic disease.
Payer LM, Burns KH. Payer LM, et al. Nat Rev Genet. 2019 Dec;20(12):760-772. doi: 10.1038/s41576-019-0165-8. Epub 2019 Sep 12. Nat Rev Genet. 2019. PMID: 31515540 Review.
Transposable elements are abundant in the human genome, and great strides have been made in pinpointing variations in these repetitive sequences using whole-genome sequencing. ...Here, we review the many ways human retrotransposons contribute to genome function, the …
Transposable elements are abundant in the human genome, and great strides have been made in pinpointing variations in these repetitiv …
A cellular taxonomy of the adult human spinal cord.
Yadav A, Matson KJE, Li L, Hua I, Petrescu J, Kang K, Alkaslasi MR, Lee DI, Hasan S, Galuta A, Dedek A, Ameri S, Parnell J, Alshardan MM, Qumqumji FA, Alhamad SM, Wang AP, Poulen G, Lonjon N, Vachiery-Lahaye F, Gaur P, Nalls MA, Qi YA, Maric D, Ward ME, Hildebrand ME, Mery PF, Bourinet E, Bauchet L, Tsai EC, Phatnani H, Le Pichon CE, Menon V, Levine AJ. Yadav A, et al. Neuron. 2023 Feb 1;111(3):328-344.e7. doi: 10.1016/j.neuron.2023.01.007. Neuron. 2023. PMID: 36731429 Free PMC article.
While animal models have advanced our understanding of spinal cellular diversity, characterizing human biology directly is important to uncover specialized features of basic function and human pathology. ...We include a web resource to facilitate further investigati …
While animal models have advanced our understanding of spinal cellular diversity, characterizing human biology directly is important …
Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons.
Jo J, Xiao Y, Sun AX, Cukuroglu E, Tran HD, Göke J, Tan ZY, Saw TY, Tan CP, Lokman H, Lee Y, Kim D, Ko HS, Kim SO, Park JH, Cho NJ, Hyde TM, Kleinman JE, Shin JH, Weinberger DR, Tan EK, Je HS, Ng HH. Jo J, et al. Cell Stem Cell. 2016 Aug 4;19(2):248-257. doi: 10.1016/j.stem.2016.07.005. Epub 2016 Jul 28. Cell Stem Cell. 2016. PMID: 27476966 Free PMC article.
We developed a method to differentiate human pluripotent stem cells into a large multicellular organoid-like structure that contains distinct layers of neuronal cells expressing characteristic markers of human midbrain. ...Thus our MLOs bearing features of the hu …
We developed a method to differentiate human pluripotent stem cells into a large multicellular organoid-like structure that contains …
Dialogue between skin microbiota and immunity.
Belkaid Y, Segre JA. Belkaid Y, et al. Science. 2014 Nov 21;346(6212):954-9. doi: 10.1126/science.1260144. Science. 2014. PMID: 25414304 Review.
Human skin, the body's largest organ, functions as a physical barrier to bar the entry of foreign pathogens, while concomitantly providing a home to myriad commensals. Over a human's life span, keratinized skin cells, immune cells, and microbes all interact t …
Human skin, the body's largest organ, functions as a physical barrier to bar the entry of foreign pathogens, while concomitantly prov …
Fragment-based design and MD simulations of human papilloma virus-16 E6 protein inhibitors.
Vemula V, Marudamuthu AS, Prasad S, B M S, S E M, A S, Seal P, Alagumuthu M. Vemula V, et al. J Biomol Struct Dyn. 2024 Jan-Feb;42(1):288-297. doi: 10.1080/07391102.2023.2203775. Epub 2023 Apr 26. J Biomol Struct Dyn. 2024. PMID: 37098806 Review.
The main objective of this study is to screen potential small molecule inhibitors against HPV (Human Papilloma Virus)-16 E6 protein (HPV16 E6P) using a fragment-based approach. ...Complexes of these compounds were stable in the 200 ns Molecular Dynamics (MD) simulat …
The main objective of this study is to screen potential small molecule inhibitors against HPV (Human Papilloma Virus)-16 E6 protein ( …
Optimizing Human Performance in ICUs.
Su L, Kudchadkar SR. Su L, et al. Pediatr Crit Care Med. 2022 Jan 1;23(1):65-67. doi: 10.1097/PCC.0000000000002845. Pediatr Crit Care Med. 2022. PMID: 34989712 No abstract available.
Investigation binding patterns of human carboxylesterase I (hCES I) with broad substrates by MD simulations.
Chu H, Min H, Zhang M, Shen H, Li G. Chu H, et al. Curr Top Med Chem. 2013;13(10):1222-33. doi: 10.2174/15680266113139990009. Curr Top Med Chem. 2013. PMID: 23647544 Review.
Human carboxylesterase I (hCES 1) plays an important role in the metabolism and activation of prodrugs, such as, the hydrolysis of a variety of drugs of prodrugs featuring an ester, amide or carbamate function. The bindings of the substrates of different lengths and cocain …
Human carboxylesterase I (hCES 1) plays an important role in the metabolism and activation of prodrugs, such as, the hydrolysis of a …
Human sialoglycan ligands for immune inhibitory Siglecs.
Gonzalez-Gil A, Li TA, Kim J, Schnaar RL. Gonzalez-Gil A, et al. Mol Aspects Med. 2023 Apr;90:101110. doi: 10.1016/j.mam.2022.101110. Epub 2022 Aug 11. Mol Aspects Med. 2023. PMID: 35965135 Review.
Siglecs have come under scrutiny as potential targets of drugs to modify the course of inflammation (and other immune system responses) and as immune checkpoints in cancer. Human Siglecs bind to endogenous human sialoglycans. The identities of these endogenous hu …
Siglecs have come under scrutiny as potential targets of drugs to modify the course of inflammation (and other immune system responses) and …
MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.
Oblak A, Pohar J, Jerala R. Oblak A, et al. PLoS One. 2015 Mar 24;10(3):e0120583. doi: 10.1371/journal.pone.0120583. eCollection 2015. PLoS One. 2015. PMID: 25803856 Free PMC article.
Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 45 …
Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Acti …
431,130 results
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