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Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.
Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC, Rentsch CT; Million Veteran Program; Davis LK, Justice AC, Sanchez-Roige S, Kampman KM, Gelernter J, Kranzler HR. Kember RL, et al. Nat Neurosci. 2022 Oct;25(10):1279-1287. doi: 10.1038/s41593-022-01160-z. Epub 2022 Sep 28. Nat Neurosci. 2022. PMID: 36171425 Free PMC article.
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.
Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Deak JD, et al. Mol Psychiatry. 2022 Oct;27(10):3970-3979. doi: 10.1038/s41380-022-01709-1. Epub 2022 Jul 25. Mol Psychiatry. 2022. PMID: 35879402 Free PMC article.