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Potent cyclic peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation.
Dutta AS, Gormley JJ, Coath M, Hassall L, Hayward CF, Gellert PR, Kittlety RS, Alcock PJ, Ferguson R, Halterman T, Jamieson A, Moors JA, Moores JM, Rees A, Wood LJ, Reilly CF, Haworth D. Dutta AS, et al. Among authors: jamieson a. J Pept Sci. 2000 Aug;6(8):398-412. doi: 10.1002/1099-1387(200008)6:8<398::AID-PSC270>3.0.CO;2-1. J Pept Sci. 2000. PMID: 10969869
Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide.
Dutta AS, Crowther M, Gormley JJ, Hassall L, Hayward CF, Gellert PR, Kittlety RS, Alcock PJ, Jamieson A, Moores JM, Rees A, Wood LJ, Reilly CF, Haworth D. Dutta AS, et al. Among authors: jamieson a. J Pept Sci. 2000 Jul;6(7):321-41. doi: 10.1002/1099-1387(200007)6:7<321::AID-PSC259>3.0.CO;2-A. J Pept Sci. 2000. PMID: 10946997
Further evidence for multiple tachykinin receptors.
Growcott JW, Jamieson A, Tarpey AV, Topham LD. Growcott JW, et al. Among authors: jamieson a. Eur J Pharmacol. 1982 Dec 17;86(1):59-64. doi: 10.1016/0014-2999(82)90396-x. Eur J Pharmacol. 1982. PMID: 6186499
Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists.
Mahindra A, Jenkins L, Marsango S, Huggett M, Huggett M, Robinson L, Gillespie J, Rajamanickam M, Morrison A, McElroy S, Tikhonova IG, Milligan G, Jamieson AG. Mahindra A, et al. Among authors: jamieson ag. J Med Chem. 2022 Aug 25;65(16):11270-11290. doi: 10.1021/acs.jmedchem.2c00804. Epub 2022 Aug 10. J Med Chem. 2022. PMID: 35948061 Free PMC article.
Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
Yelland T, Garcia E, Parry C, Kowalczyk D, Wojnowska M, Gohlke A, Zalar M, Cameron K, Goodwin G, Yu Q, Zhu PC, ElMaghloob Y, Pugliese A, Archibald L, Jamieson A, Chen YX, McArthur D, Bower J, Ismail S. Yelland T, et al. Among authors: jamieson a. J Med Chem. 2022 Feb 10;65(3):1898-1914. doi: 10.1021/acs.jmedchem.1c01265. Epub 2022 Feb 1. J Med Chem. 2022. PMID: 35104933 Free PMC article.
522 results