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DcpS as a therapeutic target for spinal muscular atrophy.
Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney ME. Singh J, et al. Among authors: jarecki j. ACS Chem Biol. 2008 Nov 21;3(11):711-22. doi: 10.1021/cb800120t. ACS Chem Biol. 2008. PMID: 18839960 Free PMC article.
Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy.
Butchbach ME, Singh J, Thorsteinsdóttir M, Saieva L, Slominski E, Thurmond J, Andrésson T, Zhang J, Edwards JD, Simard LR, Pellizzoni L, Jarecki J, Burghes AH, Gurney ME. Butchbach ME, et al. Among authors: jarecki j. Hum Mol Genet. 2010 Feb 1;19(3):454-67. doi: 10.1093/hmg/ddp510. Epub 2009 Nov 6. Hum Mol Genet. 2010. PMID: 19897588 Free PMC article.
The DcpS inhibitor RG3039 improves survival, function and motor unit pathologies in two SMA mouse models.
Gogliotti RG, Cardona H, Singh J, Bail S, Emery C, Kuntz N, Jorgensen M, Durens M, Xia B, Barlow C, Heier CR, Plasterer HL, Jacques V, Kiledjian M, Jarecki J, Rusche J, DiDonato CJ. Gogliotti RG, et al. Among authors: jarecki j. Hum Mol Genet. 2013 Oct 15;22(20):4084-101. doi: 10.1093/hmg/ddt258. Epub 2013 Jun 4. Hum Mol Genet. 2013. PMID: 23736298 Free PMC article.
Valproic acid increases SMN levels in spinal muscular atrophy patient cells.
Sumner CJ, Huynh TN, Markowitz JA, Perhac JS, Hill B, Coovert DD, Schussler K, Chen X, Jarecki J, Burghes AH, Taylor JP, Fischbeck KH. Sumner CJ, et al. Among authors: jarecki j. Ann Neurol. 2003 Nov;54(5):647-54. doi: 10.1002/ana.10743. Ann Neurol. 2003. PMID: 14595654
73 results