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Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.
Kleinman EF, Campbell E, Giordano LA, Cohan VL, Jenkinson TH, Cheng JB, Shirley JT, Pettipher ER, Salter ED, Hibbs TA, DiCapua FM, Bordner J. Kleinman EF, et al. Among authors: jenkinson th. J Med Chem. 1998 Jan 29;41(3):266-70. doi: 10.1021/jm970685m. J Med Chem. 1998. PMID: 9464356 No abstract available.