Kanagasabai R - Search Results

1

TRIM72 modulates caveolar endocytosis in repair of lung cells.

Nagre N, Wang S, Kellett T, Kanagasabai R, Deng J, Nishi M, Shilo K, Oeckler RA, Yalowich JC, Takeshima H, Christman J, Hubmayr RD, Zhao X. Nagre N, et al. Among authors: kanagasabai r. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L452-64. doi: 10.1152/ajplung.00089.2015. Epub 2015 Dec 4. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26637632 Free PMC article.

2

The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.

Yalowich JC, Wu X, Zhang R, Kanagasabai R, Hornbaker M, Hasinoff BB. Yalowich JC, et al. Among authors: kanagasabai r. Biochem Pharmacol. 2012 Jul 1;84(1):52-8. doi: 10.1016/j.bcp.2012.03.021. Epub 2012 Apr 4. Biochem Pharmacol. 2012. PMID: 22503743 Free PMC article.

3

The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform.

Kanagasabai R, Karmahapatra S, Kientz CA, Yu Y, Hernandez VA, Kania EE, Yalowich JC, Elton TS. Kanagasabai R, et al. Mol Pharmacol. 2018 May;93(5):515-525. doi: 10.1124/mol.117.111567. Epub 2018 Mar 7. Mol Pharmacol. 2018. PMID: 29514855 Free PMC article.

4

Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.

Hasinoff BB, Wu X, Patel D, Kanagasabai R, Karmahapatra S, Yalowich JC. Hasinoff BB, et al. Among authors: kanagasabai r. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409. doi: 10.1124/jpet.115.228650. Epub 2015 Dec 11. J Pharmacol Exp Ther. 2016. PMID: 26660439 Free PMC article.

5

Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.

Ren Y, Lantvit DD, Deng Y, Kanagasabai R, Gallucci JC, Ninh TN, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Swanson SM, Kinghorn AD. Ren Y, et al. Among authors: kanagasabai r. J Nat Prod. 2014 Jun 27;77(6):1494-504. doi: 10.1021/np5002785. Epub 2014 Jun 12. J Nat Prod. 2014. PMID: 24937209 Free PMC article.

6

Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform.

Kanagasabai R, Serdar L, Karmahapatra S, Kientz CA, Ellis J, Ritke MK, Elton TS, Yalowich JC. Kanagasabai R, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):152-163. doi: 10.1124/jpet.116.237107. Epub 2016 Nov 10. J Pharmacol Exp Ther. 2017. PMID: 27974648

7

Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR. Woodard JL, et al. Among authors: kanagasabai r. Bioorg Med Chem. 2018 May 15;26(9):2354-2364. doi: 10.1016/j.bmc.2018.03.033. Epub 2018 Mar 23. Bioorg Med Chem. 2018. PMID: 29656990 Free PMC article.

8

The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.

Hasinoff BB, Wu X, Nitiss JL, Kanagasabai R, Yalowich JC. Hasinoff BB, et al. Among authors: kanagasabai r. Biochem Pharmacol. 2012 Dec 15;84(12):1617-26. doi: 10.1016/j.bcp.2012.09.023. Epub 2012 Oct 5. Biochem Pharmacol. 2012. PMID: 23041231 Free PMC article.

9

Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.

Ren Y, Yuan C, Deng Y, Kanagasabai R, Ninh TN, Tu VT, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Kinghorn AD. Ren Y, et al. Among authors: kanagasabai r. Phytochemistry. 2015 Mar;111:132-40. doi: 10.1016/j.phytochem.2014.12.014. Epub 2015 Jan 14. Phytochemistry. 2015. PMID: 25596805 Free PMC article.

10

Heat shock protein 25-enriched plasma transfusion preconditions the heart against doxorubicin-induced dilated cardiomyopathy in mice.

Krishnamurthy K, Kanagasabai R, Druhan LJ, Ilangovan G. Krishnamurthy K, et al. Among authors: kanagasabai r. J Pharmacol Exp Ther. 2012 Jun;341(3):829-39. doi: 10.1124/jpet.112.192245. Epub 2012 Mar 21. J Pharmacol Exp Ther. 2012. PMID: 22438470 Free PMC article.

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