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Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D. Scherer S, et al. Among authors: kanev k. Nat Immunol. 2023 Mar;24(3):501-515. doi: 10.1038/s41590-023-01436-x. Epub 2023 Feb 16. Nat Immunol. 2023. PMID: 36797499
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D. Alfei F, et al. Among authors: kanev k. Nature. 2019 Jul;571(7764):265-269. doi: 10.1038/s41586-019-1326-9. Epub 2019 Jun 17. Nature. 2019. PMID: 31207605
Enabling single-cell trajectory network enrichment.
Grønning AGB, Oubounyt M, Kanev K, Lund J, Kacprowski T, Zehn D, Röttger R, Baumbach J. Grønning AGB, et al. Among authors: kanev k. Nat Comput Sci. 2021 Feb;1(2):153-163. doi: 10.1038/s43588-021-00025-y. Epub 2021 Feb 22. Nat Comput Sci. 2021. PMID: 38217228
Molecular RNA Correlates of the SOFA Score in Patients with Sepsis.
Meidert AS, Buschmann D, Brandes F, Kanev K, Billaud JN, Borrmann M, Witte M, Kirchner B, Reithmair M, Pfaffl MW, Schelling G. Meidert AS, et al. Among authors: kanev k. Diagnostics (Basel). 2021 Sep 9;11(9):1649. doi: 10.3390/diagnostics11091649. Diagnostics (Basel). 2021. PMID: 34573990 Free PMC article.
MYB orchestrates T cell exhaustion and response to checkpoint inhibition.
Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knöpper K, Utzschneider DT, Nüssing S, Liao Y, Mason T, Torres SV, Wilcox SA, Kanev K, Jarosch S, Leube J, Nutt SL, Zehn D, Parish IA, Kastenmüller W, Shi W, Buchholz VR, Kallies A. Tsui C, et al. Among authors: kanev k. Nature. 2022 Sep;609(7926):354-360. doi: 10.1038/s41586-022-05105-1. Epub 2022 Aug 17. Nature. 2022. PMID: 35978192 Free PMC article.
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