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Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines as highly potent EGFR-TK inhibitors with Src-family activity.
Eur J Pharm Sci. 2014 Aug 1;59:69-82. doi: 10.1016/j.ejps.2014.04.011. Epub 2014 Apr 24.
Eur J Pharm Sci. 2014.
PMID: 24769040
Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
Kaspersen SJ, Sørum C, Willassen V, Fuglseth E, Kjøbli E, Bjørkøy G, Sundby E, Hoff BH.
Kaspersen SJ, et al.
Eur J Med Chem. 2011 Dec;46(12):6002-14. doi: 10.1016/j.ejmech.2011.10.012. Epub 2011 Oct 15.
Eur J Med Chem. 2011.
PMID: 22018877
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Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena.
Kaspersen SJ, Sundby E, Charnock C, Hoff BH.
Kaspersen SJ, et al.
Bioorg Chem. 2012 Oct;44:35-41. doi: 10.1016/j.bioorg.2012.06.003. Epub 2012 Jul 6.
Bioorg Chem. 2012.
PMID: 22832269
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Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor.
Bugge S, Kaspersen SJ, Larsen S, Nonstad U, Bjørkøy G, Sundby E, Hoff BH.
Bugge S, et al. Among authors: kaspersen sj.
Eur J Med Chem. 2014 Mar 21;75:354-74. doi: 10.1016/j.ejmech.2014.01.042. Epub 2014 Jan 31.
Eur J Med Chem. 2014.
PMID: 24556149
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In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib.
Sundby E, Han J, Kaspersen SJ, Hoff BH.
Sundby E, et al. Among authors: kaspersen sj.
Eur J Pharm Sci. 2015 Dec 1;80:56-65. doi: 10.1016/j.ejps.2015.08.003. Epub 2015 Aug 19.
Eur J Pharm Sci. 2015.
PMID: 26296860
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Chiral 6-aryl-furo[2,3-d]pyrimidin-4-amines as EGFR inhibitors.
Han J, Kaspersen SJ, Nervik S, Nørsett KG, Sundby E, Hoff BH.
Han J, et al. Among authors: kaspersen sj.
Eur J Med Chem. 2016 Aug 25;119:278-99. doi: 10.1016/j.ejmech.2016.04.054. Epub 2016 Apr 25.
Eur J Med Chem. 2016.
PMID: 27235841
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