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NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.
Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA. Fang EF, et al. Among authors: kassahun h. Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004. Cell Metab. 2016. PMID: 27732836 Free PMC article.
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.
Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG. Fang EF, et al. Among authors: kassahun h. Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208. Sci Rep. 2017. PMID: 28397803 Free PMC article.
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.
Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM 3rd, Brosh RM Jr, Gorospe M, Bohr VA. Scheibye-Knudsen M, et al. Among authors: kassahun h. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507. doi: 10.1073/pnas.1610198113. Epub 2016 Oct 18. Proc Natl Acad Sci U S A. 2016. PMID: 27791127 Free PMC article.
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice.
Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA. Fang EF, et al. Among authors: kassahun h. J Vis Exp. 2017 Nov 22;(129):56301. doi: 10.3791/56301. J Vis Exp. 2017. PMID: 29286376 Free PMC article.
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA. Fang EF, et al. Among authors: kassahun h. Nat Commun. 2019 Nov 21;10(1):5284. doi: 10.1038/s41467-019-13172-8. Nat Commun. 2019. PMID: 31754102 Free PMC article.
Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology.
SenGupta T, Palikaras K, Esbensen YQ, Konstantinidis G, Galindo FJN, Achanta K, Kassahun H, Stavgiannoudaki I, Bohr VA, Akbari M, Gaare J, Tzoulis C, Tavernarakis N, Nilsen H. SenGupta T, et al. Among authors: kassahun h. Cell Rep. 2021 Sep 7;36(10):109668. doi: 10.1016/j.celrep.2021.109668. Cell Rep. 2021. PMID: 34496255 Free PMC article.
58 results