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A porcine model of neurofibromatosis type 1 that mimics the human disease.
White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, Dodd RD, Panzer K, Tang AH, Darbro BW, Moutal A, Cai S, Li W, Bellampalli SS, Khanna R, Rogers CS, Sieren JC, Quelle DE, Weimer JM. White KA, et al. Among authors: khanna r. JCI Insight. 2018 Jun 21;3(12):e120402. doi: 10.1172/jci.insight.120402. eCollection 2018 Jun 21. JCI Insight. 2018. PMID: 29925695 Free PMC article.
The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.
Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, François-Moutal L, Khanna M, Khanna R. Wilson SM, et al. Among authors: khanna r, khanna m. Front Cell Neurosci. 2014 Jul 24;8:196. doi: 10.3389/fncel.2014.00196. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25104922 Free PMC article.
A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.
François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. François-Moutal L, et al. Among authors: khanna r, khanna m. Pain. 2015 Jul;156(7):1247-1264. doi: 10.1097/j.pain.0000000000000147. Pain. 2015. PMID: 25782368 Free PMC article.
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.
Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Moutal A, et al. Among authors: khanna r. Pain Rep. 2016 Jun;1(1):e565. doi: 10.1097/PR9.0000000000000565. Pain Rep. 2016. PMID: 27917413 Free PMC article.
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.
Dustrude ET, Moutal A, Yang X, Wang Y, Khanna M, Khanna R. Dustrude ET, et al. Among authors: khanna r, khanna m. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8443-E8452. doi: 10.1073/pnas.1610531113. Epub 2016 Dec 8. Proc Natl Acad Sci U S A. 2016. PMID: 27940916 Free PMC article.
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.
Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R. Moutal A, et al. Among authors: khanna r, khanna m. Br J Pharmacol. 2018 Jun;175(12):2244-2260. doi: 10.1111/bph.13737. Epub 2017 Mar 17. Br J Pharmacol. 2018. PMID: 28161890 Free PMC article.
2,035 results