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Potent cyclic peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation.
J Pept Sci. 2000 Aug;6(8):398-412. doi: 10.1002/1099-1387(200008)6:8<398::AID-PSC270>3.0.CO;2-1.
J Pept Sci. 2000.
PMID: 10969869
Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide.
Dutta AS, Crowther M, Gormley JJ, Hassall L, Hayward CF, Gellert PR, Kittlety RS, Alcock PJ, Jamieson A, Moores JM, Rees A, Wood LJ, Reilly CF, Haworth D.
Dutta AS, et al. Among authors: kittlety rs.
J Pept Sci. 2000 Jul;6(7):321-41. doi: 10.1002/1099-1387(200007)6:7<321::AID-PSC259>3.0.CO;2-A.
J Pept Sci. 2000.
PMID: 10946997
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MRI investigation of hydration and heterogeneous degradation of aliphatic polyesters derived from lactic and glycolic acids: a controlled drug delivery device.
Djemai A, Gladden LF, Booth J, Kittlety RS, Gellert PR.
Djemai A, et al. Among authors: kittlety rs.
Magn Reson Imaging. 2001 Apr-May;19(3-4):521-3. doi: 10.1016/s0730-725x(01)00283-1.
Magn Reson Imaging. 2001.
PMID: 11445346
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The fluorescence and circular dichroism of proteins in reverse micelles: application to the photophysics of human serum albumin and N-acetyl-L-tryptophanamide.
Davis DM, McLoskey D, Birch DJ, Gellert PR, Kittlety RS, Swart RM.
Davis DM, et al. Among authors: kittlety rs.
Biophys Chem. 1996 Jun 11;60(3):63-77. doi: 10.1016/0301-4622(96)00016-6.
Biophys Chem. 1996.
PMID: 8679927
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High throughput solubility determination with application to selection of compounds for fragment screening.
Colclough N, Hunter A, Kenny PW, Kittlety RS, Lobedan L, Tam KY, Timms MA.
Colclough N, et al. Among authors: kittlety rs.
Bioorg Med Chem. 2008 Jul 1;16(13):6611-6. doi: 10.1016/j.bmc.2008.05.021. Epub 2008 May 10.
Bioorg Med Chem. 2008.
PMID: 18502135
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