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Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A. Songe-Møller L, et al. Among authors: klungland a. Mol Cell Biol. 2010 Apr;30(7):1814-27. doi: 10.1128/MCB.01602-09. Epub 2010 Feb 1. Mol Cell Biol. 2010. PMID: 20123966 Free PMC article.
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.
Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ. Zdżalik D, et al. Among authors: klungland a. PLoS One. 2014 Jun 10;9(6):e98729. doi: 10.1371/journal.pone.0098729. eCollection 2014. PLoS One. 2014. PMID: 24914785 Free PMC article.
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB. Ke S, et al. Among authors: klungland a. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24. Genes Dev. 2015. PMID: 26404942 Free PMC article.
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M. Bjørge MD, et al. Among authors: klungland a. Cell Rep. 2015 Dec 29;13(12):2671-8. doi: 10.1016/j.celrep.2015.12.001. Epub 2015 Dec 17. Cell Rep. 2015. PMID: 26711335 Free article.
151 results