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A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile.
Lenkowski PW, Batts TW, Smith MD, Ko SH, Jones PJ, Taylor CH, McCusker AK, Davis GC, Hartmann HA, White HS, Brown ML, Patel MK. Lenkowski PW, et al. Among authors: ko sh. Neuropharmacology. 2007 Mar;52(3):1044-54. doi: 10.1016/j.neuropharm.2006.11.001. Epub 2006 Dec 14. Neuropharmacology. 2007. PMID: 17174360 Free PMC article.
5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo.
Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. Todorovic SM, et al. Among authors: ko sh. Mol Pharmacol. 2004 Nov;66(5):1223-35. doi: 10.1124/mol.104.002402. Epub 2004 Jul 27. Mol Pharmacol. 2004. PMID: 15280444
786 results