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Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.
Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D. Pettersen EO, et al. Among authors: koritzinsky m. J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. J Enzyme Inhib Med Chem. 2015. PMID: 25347767 Review.
Hypoxia as a target for combined modality treatments.
Wouters BG, Weppler SA, Koritzinsky M, Landuyt W, Nuyts S, Theys J, Chiu RK, Lambin P. Wouters BG, et al. Among authors: koritzinsky m. Eur J Cancer. 2002 Jan;38(2):240-57. doi: 10.1016/s0959-8049(01)00361-6. Eur J Cancer. 2002. PMID: 11803141 Review.
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.
Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C, Miller C, Demonacos C, Stratford IJ, Dive C. Erler JT, et al. Among authors: koritzinsky m. Mol Cell Biol. 2004 Apr;24(7):2875-89. doi: 10.1128/MCB.24.7.2875-2889.2004. Mol Cell Biol. 2004. PMID: 15024076 Free PMC article.
Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress.
Magagnin MG, Sergeant K, van den Beucken T, Rouschop KM, Jutten B, Seigneuric R, Lambin P, Devreese B, Koritzinsky M, Wouters BG. Magagnin MG, et al. Among authors: koritzinsky m. Radiother Oncol. 2007 Jun;83(3):340-5. doi: 10.1016/j.radonc.2007.04.027. Epub 2007 May 24. Radiother Oncol. 2007. PMID: 17531340
77 results