Kudlacz EM - Search Results

1

Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists.

Duplantier AJ, Beckius GE, Chambers RJ, Chupak LS, Jenkinson TH, Klein AS, Kraus KG, Kudlacz EM, McKechney MW, Pettersson MP, Whitney CA, Milici AJ. Duplantier AJ, et al. Among authors: kudlacz em. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2593-6. doi: 10.1016/s0960-894x(01)00511-x. Bioorg Med Chem Lett. 2001. PMID: 11551757

2

Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists.

Kudlacz E, Whitney C, Andresen C, Duplantier A, Beckius G, Chupak L, Klein A, Kraus K, Milici A. Kudlacz E, et al. J Pharmacol Exp Ther. 2002 May;301(2):747-52. doi: 10.1124/jpet.301.2.747. J Pharmacol Exp Ther. 2002. PMID: 11961081

3

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis.

Milici AJ, Kudlacz EM, Audoly L, Zwillich S, Changelian P. Milici AJ, et al. Among authors: kudlacz em. Arthritis Res Ther. 2008;10(1):R14. doi: 10.1186/ar2365. Epub 2008 Jan 30. Arthritis Res Ther. 2008. PMID: 18234077 Free PMC article.

4

Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat.

Kudlacz EM, Whitney CA, Andresen CJ, Umland JP, Cheng JB. Kudlacz EM, et al. Br J Pharmacol. 1999 Oct;128(3):788-94. doi: 10.1038/sj.bjp.0702835. Br J Pharmacol. 1999. PMID: 10516663 Free PMC article.

5

Genetic ablation of the src kinase p59fynT exacerbates pulmonary inflammation in an allergic mouse model.

Kudlacz EM, Andresen CJ, Salafia M, Whitney CA, Naclerio B, Changelian PS. Kudlacz EM, et al. Am J Respir Cell Mol Biol. 2001 Apr;24(4):469-74. doi: 10.1165/ajrcmb.24.4.4266. Am J Respir Cell Mol Biol. 2001. PMID: 11306441

6

Functional effects of eotaxin are selectively upregulated on IL-5 transgenic mouse eosinophils.

Kudlacz E, Whitney C, Andresenl C, Conklyn M. Kudlacz E, et al. Inflammation. 2002 Jun;26(3):111-9. doi: 10.1023/a:1015548414274. Inflammation. 2002. PMID: 12083417

7

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

Changelian PS, Flanagan ME, Ball DJ, Kent CR, Magnuson KS, Martin WH, Rizzuti BJ, Sawyer PS, Perry BD, Brissette WH, McCurdy SP, Kudlacz EM, Conklyn MJ, Elliott EA, Koslov ER, Fisher MB, Strelevitz TJ, Yoon K, Whipple DA, Sun J, Munchhof MJ, Doty JL, Casavant JM, Blumenkopf TA, Hines M, Brown MF, Lillie BM, Subramanyam C, Shang-Poa C, Milici AJ, Beckius GE, Moyer JD, Su C, Woodworth TG, Gaweco AS, Beals CR, Littman BH, Fisher DA, Smith JF, Zagouras P, Magna HA, Saltarelli MJ, Johnson KS, Nelms LF, Des Etages SG, Hayes LS, Kawabata TT, Finco-Kent D, Baker DL, Larson M, Si MS, Paniagua R, Higgins J, Holm B, Reitz B, Zhou YJ, Morris RE, O'Shea JJ, Borie DC. Changelian PS, et al. Among authors: kudlacz em. Science. 2003 Oct 31;302(5646):875-8. doi: 10.1126/science.1087061. Science. 2003. PMID: 14593182

8

Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.

Flanagan ME, Blumenkopf TA, Brissette WH, Brown MF, Casavant JM, Shang-Poa C, Doty JL, Elliott EA, Fisher MB, Hines M, Kent C, Kudlacz EM, Lillie BM, Magnuson KS, McCurdy SP, Munchhof MJ, Perry BD, Sawyer PS, Strelevitz TJ, Subramanyam C, Sun J, Whipple DA, Changelian PS. Flanagan ME, et al. Among authors: kudlacz em. J Med Chem. 2010 Dec 23;53(24):8468-84. doi: 10.1021/jm1004286. Epub 2010 Nov 24. J Med Chem. 2010. PMID: 21105711

9

PF-03475952: a potent and neutralizing fully human anti-CD44 antibody for therapeutic applications in inflammatory diseases.

Runnels HA, Weber GL, Min J, Kudlacz EM, Zobel JF, Donovan CB, Thiede MA, Zhang J, Alpert RB, Salafia MA, Milici AJ, Burdette D, Bell RR, Beebe JS, Xu X. Runnels HA, et al. Among authors: kudlacz em. Adv Ther. 2010 Mar;27(3):168-80. doi: 10.1007/s12325-010-0010-0. Epub 2010 Apr 26. Adv Ther. 2010. PMID: 20429046

10

The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models.

Kudlacz E, Perry B, Sawyer P, Conklyn M, McCurdy S, Brissette W, Flanagan And M, Changelian P. Kudlacz E, et al. Am J Transplant. 2004 Jan;4(1):51-7. doi: 10.1046/j.1600-6143.2003.00281.x. Am J Transplant. 2004. PMID: 14678034 Free article.

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