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Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.
Luci DK, Jameson JB 2nd, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ. Luci DK, et al. Among authors: kuhn n. J Med Chem. 2014 Jan 23;57(2):495-506. doi: 10.1021/jm4016476. Epub 2014 Jan 6. J Med Chem. 2014. PMID: 24393039 Free PMC article.
Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.
Green-Mitchell SM, Tersey SA, Cole BK, Ma K, Kuhn NS, Cunningham TD, Maybee NA, Chakrabarti SK, McDuffie M, Taylor-Fishwick DA, Mirmira RG, Nadler JL, Morris MA. Green-Mitchell SM, et al. PLoS One. 2013;8(2):e56763. doi: 10.1371/journal.pone.0056763. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437231 Free PMC article.
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
Cole BK, Kuhn NS, Green-Mitchell SM, Leone KA, Raab RM, Nadler JL, Chakrabarti SK. Cole BK, et al. Am J Physiol Endocrinol Metab. 2012 Mar 15;302(6):E654-65. doi: 10.1152/ajpendo.00373.2011. Epub 2012 Jan 3. Am J Physiol Endocrinol Metab. 2012. PMID: 22215650 Free PMC article.
Production and function of IL-12 in islets and beta cells.
Taylor-Fishwick DA, Weaver JR, Grzesik W, Chakrabarti S, Green-Mitchell S, Imai Y, Kuhn N, Nadler JL. Taylor-Fishwick DA, et al. Among authors: kuhn n. Diabetologia. 2013 Jan;56(1):126-35. doi: 10.1007/s00125-012-2732-9. Epub 2012 Oct 3. Diabetologia. 2013. PMID: 23052055 Free PMC article.
226 results