Kuhn PH - Search Results

1

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D. Schwenk BM, et al. Among authors: kuhn ph. EMBO J. 2016 Nov 2;35(21):2350-2370. doi: 10.15252/embj.201694221. Epub 2016 Sep 12. EMBO J. 2016. PMID: 27621269 Free PMC article.

2

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.

Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF. Kuhn PH, et al. EMBO J. 2010 Sep 1;29(17):3020-32. doi: 10.1038/emboj.2010.167. Epub 2010 Jul 30. EMBO J. 2010. PMID: 20676056 Free PMC article.

3

Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.

Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF. Hogl S, et al. Among authors: kuhn ph. PLoS One. 2011;6(6):e21337. doi: 10.1371/journal.pone.0021337. Epub 2011 Jun 17. PLoS One. 2011. PMID: 21695060 Free PMC article.

4

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration.

Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C. Lang CM, et al. Among authors: kuhn ph. J Biol Chem. 2012 Jun 1;287(23):19355-65. doi: 10.1074/jbc.M112.365098. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511793 Free PMC article.

5

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. Kuhn PH, et al. EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173. EMBO J. 2012. PMID: 22728825 Free PMC article.

6

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF. Colombo A, et al. Among authors: kuhn ph. Neurobiol Dis. 2013 Jan;49:137-47. doi: 10.1016/j.nbd.2012.08.011. Epub 2012 Aug 24. Neurobiol Dis. 2013. PMID: 22940630 Free PMC article.

7

Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments.

Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C. Page RM, et al. Among authors: kuhn ph. J Neurosci. 2012 Dec 12;32(50):18204-14. doi: 10.1523/JNEUROSCI.2681-12.2012. J Neurosci. 2012. PMID: 23238734 Free PMC article.

8

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.

Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R. Voss M, et al. Among authors: kuhn ph. EMBO J. 2014 Dec 17;33(24):2890-905. doi: 10.15252/embj.201488375. Epub 2014 Oct 29. EMBO J. 2014. PMID: 25354954 Free PMC article.

9

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.

Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF. Kuhn PH, et al. Elife. 2016 Jan 23;5:e12748. doi: 10.7554/eLife.12748. Elife. 2016. PMID: 26802628 Free PMC article.

10

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.

Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. Kretner B, et al. Among authors: kuhn ph. EMBO Mol Med. 2016 May 2;8(5):458-65. doi: 10.15252/emmm.201505952. Print 2016 May. EMBO Mol Med. 2016. PMID: 26988102 Free PMC article.

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