Kyle DE - Search Results

1

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta.

Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH. Shao CL, et al. Among authors: kyle de. J Org Chem. 2015 Aug 21;80(16):7849-55. doi: 10.1021/acs.joc.5b01264. Epub 2015 Aug 5. J Org Chem. 2015. PMID: 26222145

2

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

Linington RG, Clark BR, Trimble EE, Almanza A, Ureña LD, Kyle DE, Gerwick WH. Linington RG, et al. Among authors: kyle de. J Nat Prod. 2009 Jan;72(1):14-7. doi: 10.1021/np8003529. J Nat Prod. 2009. PMID: 19161344 Free PMC article.

3

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds.

Sanchez LM, Lopez D, Vesely BA, Della Togna G, Gerwick WH, Kyle DE, Linington RG. Sanchez LM, et al. Among authors: kyle de. J Med Chem. 2010 May 27;53(10):4187-97. doi: 10.1021/jm100265s. J Med Chem. 2010. PMID: 20441198 Free PMC article.

4

Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.

Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH. Balunas MJ, et al. Among authors: kyle de. Org Lett. 2012 Aug 3;14(15):3878-81. doi: 10.1021/ol301607q. Epub 2012 Jul 13. Org Lett. 2012. PMID: 22794317 Free PMC article.

5

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R. Cross RM, et al. Among authors: kyle de. J Med Chem. 2010 Oct 14;53(19):7076-94. doi: 10.1021/jm1007903. J Med Chem. 2010. PMID: 20828199

6

Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships.

Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Cross RM, et al. Among authors: kyle de. J Med Chem. 2011 Jul 14;54(13):4399-426. doi: 10.1021/jm200015a. Epub 2011 Jun 16. J Med Chem. 2011. PMID: 21630666

7

Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum.

Tucker MS, Mutka T, Sparks K, Patel J, Kyle DE. Tucker MS, et al. Among authors: kyle de. Antimicrob Agents Chemother. 2012 Jan;56(1):302-14. doi: 10.1128/AAC.05540-11. Epub 2011 Nov 14. Antimicrob Agents Chemother. 2012. PMID: 22083467 Free PMC article.

8

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.

Cross RM, Namelikonda NK, Mutka TS, Luong L, Kyle DE, Manetsch R. Cross RM, et al. Among authors: kyle de. J Med Chem. 2011 Dec 22;54(24):8321-7. doi: 10.1021/jm200718m. Epub 2011 Nov 23. J Med Chem. 2011. PMID: 22111907 Free PMC article.

9

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity.

Maignan JR, Lichorowic CL, Giarrusso J, Blake LD, Casandra D, Mutka TS, LaCrue AN, Burrows JN, Willis PA, Kyle DE, Manetsch R. Maignan JR, et al. Among authors: kyle de. J Med Chem. 2016 Jul 28;59(14):6943-60. doi: 10.1021/acs.jmedchem.6b00759. Epub 2016 Jul 12. J Med Chem. 2016. PMID: 27291102 Free PMC article.

10

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.

Neelarapu R, Maignan JR, Lichorowic CL, Monastyrskyi A, Mutka TS, LaCrue AN, Blake LD, Casandra D, Mashkouri S, Burrows JN, Willis PA, Kyle DE, Manetsch R. Neelarapu R, et al. Among authors: kyle de. J Med Chem. 2018 Feb 22;61(4):1450-1473. doi: 10.1021/acs.jmedchem.7b00738. Epub 2018 Feb 9. J Med Chem. 2018. PMID: 29215279 Free PMC article.

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