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Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.
Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D. Pettersen EO, et al. Among authors: lambin p. J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. J Enzyme Inhib Med Chem. 2015. PMID: 25347767 Review.
Hypoxia as a target for combined modality treatments.
Wouters BG, Weppler SA, Koritzinsky M, Landuyt W, Nuyts S, Theys J, Chiu RK, Lambin P. Wouters BG, et al. Among authors: lambin p. Eur J Cancer. 2002 Jan;38(2):240-57. doi: 10.1016/s0959-8049(01)00361-6. Eur J Cancer. 2002. PMID: 11803141 Review.
Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress.
Magagnin MG, Sergeant K, van den Beucken T, Rouschop KM, Jutten B, Seigneuric R, Lambin P, Devreese B, Koritzinsky M, Wouters BG. Magagnin MG, et al. Among authors: lambin p. Radiother Oncol. 2007 Jun;83(3):340-5. doi: 10.1016/j.radonc.2007.04.027. Epub 2007 May 24. Radiother Oncol. 2007. PMID: 17531340
Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types.
Starmans MH, Krishnapuram B, Steck H, Horlings H, Nuyten DS, van de Vijver MJ, Seigneuric R, Buffa FM, Harris AL, Wouters BG, Lambin P. Starmans MH, et al. Among authors: lambin p. Br J Cancer. 2008 Dec 2;99(11):1884-90. doi: 10.1038/sj.bjc.6604746. Epub 2008 Nov 4. Br J Cancer. 2008. PMID: 18985037 Free PMC article.
Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.
Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, Kanopka A, Görlach A, Gasmann M, Harris AL, Maxwell P, Scozzafava A. Ebbesen P, et al. Among authors: lambin p. J Enzyme Inhib Med Chem. 2009 Apr;24 Suppl 1:1-39. doi: 10.1080/14756360902784425. J Enzyme Inhib Med Chem. 2009. PMID: 19330638 Free article. Review.
Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response.
van den Beucken T, Koritzinsky M, Niessen H, Dubois L, Savelkouls K, Mujcic H, Jutten B, Kopacek J, Pastorekova S, van der Kogel AJ, Lambin P, Voncken W, Rouschop KM, Wouters BG. van den Beucken T, et al. Among authors: lambin p. J Biol Chem. 2009 Sep 4;284(36):24204-12. doi: 10.1074/jbc.M109.006510. Epub 2009 Jun 29. J Biol Chem. 2009. PMID: 19564335 Free PMC article.
775 results