Langmead CJ - Search Results

1

From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.

Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB. Brown AJH, et al. Among authors: langmead cj. Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001. Cell. 2021. PMID: 34822784 Free article. Clinical Trial.

2

Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist.

Langmead CJ, Fry VA, Forbes IT, Branch CL, Christopoulos A, Wood MD, Herdon HJ. Langmead CJ, et al. Mol Pharmacol. 2006 Jan;69(1):236-46. doi: 10.1124/mol.105.017814. Epub 2005 Oct 5. Mol Pharmacol. 2006. PMID: 16207821

3

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox.

Langmead CJ, Christopoulos A. Langmead CJ, et al. Trends Pharmacol Sci. 2006 Sep;27(9):475-81. doi: 10.1016/j.tips.2006.07.009. Epub 2006 Aug 4. Trends Pharmacol Sci. 2006. PMID: 16889837 Review.

4

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

May LT, Avlani VA, Langmead CJ, Herdon HJ, Wood MD, Sexton PM, Christopoulos A. May LT, et al. Among authors: langmead cj. Mol Pharmacol. 2007 Aug;72(2):463-76. doi: 10.1124/mol.107.037630. Epub 2007 May 24. Mol Pharmacol. 2007. PMID: 17525129

5

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1.

Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VA, Hagan JJ, Herdon HJ, Jones GA, Jeggo R, Kew JN, Mazzali A, Melarange R, Patel N, Pardoe J, Randall AD, Roberts C, Roopun A, Starr KR, Teriakidis A, Wood MD, Whittington M, Wu Z, Watson J. Langmead CJ, et al. Br J Pharmacol. 2008 Jul;154(5):1104-15. doi: 10.1038/bjp.2008.152. Epub 2008 May 5. Br J Pharmacol. 2008. PMID: 18454168 Free PMC article.

6

Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.

Bennett KA, Langmead CJ, Wise A, Milligan G. Bennett KA, et al. Among authors: langmead cj. Mol Pharmacol. 2009 Oct;76(4):802-11. doi: 10.1124/mol.109.056101. Epub 2009 Jul 22. Mol Pharmacol. 2009. PMID: 19625579 Free PMC article.

7

Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.

Avlani VA, Langmead CJ, Guida E, Wood MD, Tehan BG, Herdon HJ, Watson JM, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: langmead cj. Mol Pharmacol. 2010 Jul;78(1):94-104. doi: 10.1124/mol.110.064345. Epub 2010 Apr 22. Mol Pharmacol. 2010. PMID: 20413650

8

The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery.

Robertson N, Jazayeri A, Errey J, Baig A, Hurrell E, Zhukov A, Langmead CJ, Weir M, Marshall FH. Robertson N, et al. Among authors: langmead cj. Neuropharmacology. 2011 Jan;60(1):36-44. doi: 10.1016/j.neuropharm.2010.07.001. Epub 2010 Jul 17. Neuropharmacology. 2011. PMID: 20624408

9

Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia.

Bradley SJ, Langmead CJ, Watson JM, Challiss RA. Bradley SJ, et al. Among authors: langmead cj. Mol Pharmacol. 2011 May;79(5):874-85. doi: 10.1124/mol.110.068882. Epub 2011 Feb 14. Mol Pharmacol. 2011. PMID: 21321061 Free PMC article.

10

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation.

Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Lebon G, et al. Among authors: langmead cj. Nature. 2011 May 18;474(7352):521-5. doi: 10.1038/nature10136. Nature. 2011. PMID: 21593763 Free PMC article.

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