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A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function.
Blood. 2008 Sep 1;112(5):2055-61. doi: 10.1182/blood-2008-04-150276. Epub 2008 Jun 17.
Blood. 2008.
PMID: 18559978
Free article.
Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.
Lasry I, Berman B, Glaser F, Jansen G, Assaraf YG.
Lasry I, et al.
Biochem Biophys Res Commun. 2009 Aug 28;386(3):426-31. doi: 10.1016/j.bbrc.2009.06.007. Epub 2009 Jun 7.
Biochem Biophys Res Commun. 2009.
PMID: 19508863
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A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency.
Lasry I, Seo YA, Ityel H, Shalva N, Pode-Shakked B, Glaser F, Berman B, Berezovsky I, Goncearenco A, Klar A, Levy J, Anikster Y, Kelleher SL, Assaraf YG.
Lasry I, et al.
J Biol Chem. 2012 Aug 24;287(35):29348-61. doi: 10.1074/jbc.M112.368159. Epub 2012 Jun 25.
J Biol Chem. 2012.
PMID: 22733820
Free PMC article.
Clinical Trial.
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In situ dimerization of multiple wild type and mutant zinc transporters in live cells using bimolecular fluorescence complementation.
Lasry I, Golan Y, Berman B, Amram N, Glaser F, Assaraf YG.
Lasry I, et al.
J Biol Chem. 2014 Mar 14;289(11):7275-92. doi: 10.1074/jbc.M113.533786. Epub 2014 Jan 22.
J Biol Chem. 2014.
PMID: 24451381
Free PMC article.
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Folic Acid Impairs the Uptake of 5-Methyltetrahydrofolate in Human Umbilical Vascular Endothelial Cells.
Smith D, Hornstra J, Rocha M, Jansen G, Assaraf Y, Lasry I, Blom H, Smulders YM.
Smith D, et al. Among authors: lasry i.
J Cardiovasc Pharmacol. 2017 Oct;70(4):271-275. doi: 10.1097/FJC.0000000000000514.
J Cardiovasc Pharmacol. 2017.
PMID: 28991880
Free PMC article.
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USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
Goldbraikh D, Neufeld D, Eid-Mutlak Y, Lasry I, Gilda JE, Parnis A, Cohen S.
Goldbraikh D, et al. Among authors: lasry i.
EMBO Rep. 2020 Apr 3;21(4):e48791. doi: 10.15252/embr.201948791. Epub 2020 Mar 5.
EMBO Rep. 2020.
PMID: 32133736
Free PMC article.
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