Lawson ADG - Search Results

1

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein-Protein Interactions (PPIs) through Stabilization of Desired Conformers.

Lawson ADG, MacCoss M, Heer JP. Lawson ADG, et al. J Med Chem. 2018 May 24;61(10):4283-4289. doi: 10.1021/acs.jmedchem.7b01120. Epub 2017 Nov 28. J Med Chem. 2018. PMID: 29140691 Free article.

2

Rings in drugs.

Taylor RD, MacCoss M, Lawson AD. Taylor RD, et al. J Med Chem. 2014 Jul 24;57(14):5845-59. doi: 10.1021/jm4017625. Epub 2014 Feb 17. J Med Chem. 2014. PMID: 24471928 Review.

3

G Protein-Coupled Receptors - Targets for Fragment-based Drug Discovery.

Lawson AD. Lawson AD. Curr Top Med Chem. 2015;15(24):2523-7. doi: 10.2174/1568026615666150701113151. Curr Top Med Chem. 2015. PMID: 26126904 Review.

4

Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics.

Cossins BP, Lawson AD. Cossins BP, et al. Molecules. 2015 Sep 10;20(9):16435-45. doi: 10.3390/molecules200916435. Molecules. 2015. PMID: 26378508 Free PMC article. Review.

5

Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery.

Taylor RD, MacCoss M, Lawson AD. Taylor RD, et al. J Med Chem. 2017 Mar 9;60(5):1638-1647. doi: 10.1021/acs.jmedchem.6b01367. Epub 2016 Dec 23. J Med Chem. 2017. PMID: 27935308 Review.

6

Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules.

Lawson ADG, MacCoss M, Baeten DL, Macpherson A, Shi J, Henry AJ. Lawson ADG, et al. Front Chem. 2021 May 4;9:668186. doi: 10.3389/fchem.2021.668186. eCollection 2021. Front Chem. 2021. PMID: 34017820 Free PMC article.

7

Rings in Clinical Trials and Drugs: Present and Future.

Shearer J, Castro JL, Lawson ADG, MacCoss M, Taylor RD. Shearer J, et al. Among authors: lawson adg. J Med Chem. 2022 Jul 14;65(13):8699-8712. doi: 10.1021/acs.jmedchem.2c00473. Epub 2022 Jun 22. J Med Chem. 2022. PMID: 35730680 Free PMC article. Review.

8

Antibody fragments as tools in crystallography.

Griffin L, Lawson A. Griffin L, et al. Clin Exp Immunol. 2011 Sep;165(3):285-91. doi: 10.1111/j.1365-2249.2011.04427.x. Epub 2011 Jun 7. Clin Exp Immunol. 2011. PMID: 21649648 Free PMC article. Review.

9

Computational Exploration of Conformational Transitions in Protein Drug Targets.

Cossins BP, Lawson ADG, Shi J. Cossins BP, et al. Among authors: lawson adg. Methods Mol Biol. 2018;1762:339-365. doi: 10.1007/978-1-4939-7756-7_17. Methods Mol Biol. 2018. PMID: 29594780

10

The rational design of affinity-attenuated OmCI for the purification of complement C5.

Macpherson A, Liu X, Dedi N, Kennedy J, Carrington B, Durrant O, Heywood S, van den Elsen J, Lawson ADG. Macpherson A, et al. Among authors: lawson adg. J Biol Chem. 2018 Sep 7;293(36):14112-14121. doi: 10.1074/jbc.RA118.004043. Epub 2018 Jul 20. J Biol Chem. 2018. PMID: 30030376 Free PMC article.

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