LeCluyse E - Search Results

1

Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing.

Lu J, Einhorn S, Venkatarangan L, Miller M, Mann DA, Watkins PB, LeCluyse E. Lu J, et al. Among authors: lecluyse e. Toxicol Sci. 2015 Sep;147(1):39-54. doi: 10.1093/toxsci/kfv117. Epub 2015 Jun 18. Toxicol Sci. 2015. PMID: 26092927

2

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

Mosedale M, Eaddy JS, Trask OJ Jr, Holman NS, Wolf KK, LeCluyse E, Ware BR, Khetani SR, Lu J, Brock WJ, Roth SE, Watkins PB. Mosedale M, et al. Among authors: lecluyse e. Toxicol Sci. 2018 Jan 1;161(1):149-158. doi: 10.1093/toxsci/kfx206. Toxicol Sci. 2018. PMID: 29029277 Free PMC article.

3

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M. Holman NS, et al. Among authors: lecluyse e. Toxicol Sci. 2019 Aug 1;170(2):499-508. doi: 10.1093/toxsci/kfz112. Toxicol Sci. 2019. PMID: 31093666 Free PMC article.

4

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Holman NS, Mosedale M, Wolf KK, LeCluyse EL, Watkins PB. Holman NS, et al. Toxicol Sci. 2016 Jun;151(2):365-75. doi: 10.1093/toxsci/kfw047. Epub 2016 Mar 8. Toxicol Sci. 2016. PMID: 26962055 Free PMC article.

5

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260.

Harrill AH, Eaddy JS, Rose K, Cullen JM, Ramanathan L, Wanaski S, Collins S, Ho Y, Watkins PB, Lecluyse EL. Harrill AH, et al. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):131-7. doi: 10.1016/j.taap.2014.03.015. Epub 2014 Mar 31. Toxicol Appl Pharmacol. 2014. PMID: 24699182

6

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Black MB, Budinsky RA, Dombkowski A, Cukovic D, LeCluyse EL, Ferguson SS, Thomas RS, Rowlands JC. Black MB, et al. Toxicol Sci. 2012 May;127(1):199-215. doi: 10.1093/toxsci/kfs069. Epub 2012 Feb 1. Toxicol Sci. 2012. PMID: 22298810

7

A map of the PPARα transcription regulatory network for primary human hepatocytes.

McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME. McMullen PD, et al. Among authors: lecluyse el. Chem Biol Interact. 2014 Feb 25;209:14-24. doi: 10.1016/j.cbi.2013.11.006. Epub 2013 Nov 22. Chem Biol Interact. 2014. PMID: 24269660 Free article.

8

Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.

Norona LM, Nguyen DG, Gerber DA, Presnell SC, LeCluyse EL. Norona LM, et al. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7. Toxicol Sci. 2016. PMID: 27605418 Free PMC article.

9

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.

Wetmore BA, Wambaugh JF, Allen B, Ferguson SS, Sochaski MA, Setzer RW, Houck KA, Strope CL, Cantwell K, Judson RS, LeCluyse E, Clewell HJ, Thomas RS, Andersen ME. Wetmore BA, et al. Among authors: lecluyse e. Toxicol Sci. 2015 Nov;148(1):121-36. doi: 10.1093/toxsci/kfv171. Epub 2015 Aug 6. Toxicol Sci. 2015. PMID: 26251325 Free PMC article.

10

Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification.

Tikunov AP, Shim YS, Bhattarai N, Siler SQ, Soldatow V, LeCluyse EL, McDunn JE, Watkins PB, Macdonald JM. Tikunov AP, et al. Among authors: lecluyse el. Toxicol In Vitro. 2017 Dec;45(Pt 1):119-127. doi: 10.1016/j.tiv.2017.08.021. Epub 2017 Sep 1. Toxicol In Vitro. 2017. PMID: 28867505

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