Lee WC - Search Results

1

Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.

Lin Kc, Ateeq HS, Hsiung SH, Chong LT, Zimmerman CN, Castro A, Lee WC, Hammond CE, Kalkunte S, Chen LL, Pepinsky RB, Leone DR, Sprague AG, Abraham WM, Gill A, Lobb RR, Adams SP. Lin Kc, et al. Among authors: lee wc. J Med Chem. 1999 Mar 11;42(5):920-34. doi: 10.1021/jm980673g. J Med Chem. 1999. PMID: 10072689

2

Identification of potent and novel alpha4beta1 antagonists using in silico screening.

Singh J, Van Vlijmen H, Liao Y, Lee WC, Cornebise M, Harris M, Shu IH, Gill A, Cuervo JH, Abraham WM, Adams SP. Singh J, et al. Among authors: lee wc. J Med Chem. 2002 Jul 4;45(14):2988-93. doi: 10.1021/jm020054e. J Med Chem. 2002. PMID: 12086484

3

Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma.

Singh J, Adams S, Carter MB, Cuervo H, Lee WC, Lobb RR, Pepinsky RB, Petter R, Scott D. Singh J, et al. Among authors: lee wc. Curr Top Med Chem. 2004;4(14):1497-507. doi: 10.2174/1568026043387520. Curr Top Med Chem. 2004. PMID: 15544540 Review.

4

Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium.

Chen LL, Whitty A, Scott D, Lee WC, Cornebise M, Adams SP, Petter RC, Lobb RR, Pepinsky RB. Chen LL, et al. Among authors: lee wc. J Biol Chem. 2001 Sep 28;276(39):36520-9. doi: 10.1074/jbc.M106216200. Epub 2001 Jul 25. J Biol Chem. 2001. PMID: 11473127 Free article.

5

Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI).

Singh J, Chuaqui CE, Boriack-Sjodin PA, Lee WC, Pontz T, Corbley MJ, Cheung HK, Arduini RM, Mead JN, Newman MN, Papadatos JL, Bowes S, Josiah S, Ling LE. Singh J, et al. Among authors: lee wc. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4355-9. doi: 10.1016/j.bmcl.2003.09.028. Bioorg Med Chem Lett. 2003. PMID: 14643325

6

A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.

Egger LA, Cao J, McCallum C, Kidambi U, Van Riper G, McCauley E, Mumford RA, Lanza TJ, Lin LS, de Laszlo SE, Young DN, Yang G, Dean DC, Raab CE, Wallace MA, Jones AN, Hagmann WK, Schmidt JA, Pepinsky RB, Scott DM, Lee WC, Cornebise MA, Detmers PA. Egger LA, et al. Among authors: lee wc. J Pharmacol Exp Ther. 2003 Sep;306(3):903-13. doi: 10.1124/jpet.102.047704. Epub 2003 May 23. J Pharmacol Exp Ther. 2003. PMID: 12766251

7

Heat shock protein 90: inhibitors in clinical trials.

Biamonte MA, Van de Water R, Arndt JW, Scannevin RH, Perret D, Lee WC. Biamonte MA, et al. Among authors: lee wc. J Med Chem. 2010 Jan 14;53(1):3-17. doi: 10.1021/jm9004708. J Med Chem. 2010. PMID: 20055425 No abstract available.

8

Pyrazolone based TGFbetaR1 kinase inhibitors.

Guckian K, Carter MB, Lin EY, Choi M, Sun L, Boriack-Sjodin PA, Chuaqui C, Lane B, Cheung K, Ling L, Lee WC. Guckian K, et al. Among authors: lee wc. Bioorg Med Chem Lett. 2010 Jan 1;20(1):326-9. doi: 10.1016/j.bmcl.2009.10.108. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19914068

9

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.

Fu K, Corbley MJ, Sun L, Friedman JE, Shan F, Papadatos JL, Costa D, Lutterodt F, Sweigard H, Bowes S, Choi M, Boriack-Sjodin PA, Arduini RM, Sun D, Newman MN, Zhang X, Mead JN, Chuaqui CE, Cheung HK, Zhang X, Cornebise M, Carter MB, Josiah S, Singh J, Lee WC, Gill A, Ling LE. Fu K, et al. Among authors: lee wc. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. doi: 10.1161/ATVBAHA.107.158030. Epub 2008 Jan 17. Arterioscler Thromb Vasc Biol. 2008. PMID: 18202322

10

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).

Zhang L, Fan J, Chong JH, Cesena A, Tam BY, Gilson C, Boykin C, Wang D, Aivazian D, Marcotte D, Xiao G, Le Brazidec JY, Piao J, Lundgren K, Hong K, Vu K, Nguyen K, Gan LS, Silvian L, Ling L, Teng M, Reff M, Takeda N, Timple N, Wang Q, Morena R, Khan S, Zhao S, Li T, Lee WC, Taveras AG, Chao J. Zhang L, et al. Among authors: lee wc. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5633-7. doi: 10.1016/j.bmcl.2011.06.129. Epub 2011 Jul 13. Bioorg Med Chem Lett. 2011. PMID: 21798738

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