Lemgruber L - Search Results

1

Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation.

Marques CA, Tiengwe C, Lemgruber L, Damasceno JD, Scott A, Paape D, Marcello L, McCulloch R. Marques CA, et al. Among authors: lemgruber l. Nucleic Acids Res. 2016 Jun 2;44(10):4763-84. doi: 10.1093/nar/gkw147. Epub 2016 Mar 6. Nucleic Acids Res. 2016. PMID: 26951375 Free PMC article.

2

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.

Millan CR, Acosta-Reyes FJ, Lagartera L, Ebiloma GU, Lemgruber L, Nué Martínez JJ, Saperas N, Dardonville C, de Koning HP, Campos JL. Millan CR, et al. Among authors: lemgruber l. Nucleic Acids Res. 2017 Aug 21;45(14):8378-8391. doi: 10.1093/nar/gkx521. Nucleic Acids Res. 2017. PMID: 28637278 Free PMC article.

3

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.

Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandez-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC, McCulloch R. Stortz JA, et al. Among authors: lemgruber l. PLoS Pathog. 2017 Jul 24;13(7):e1006477. doi: 10.1371/journal.ppat.1006477. eCollection 2017 Jul. PLoS Pathog. 2017. PMID: 28742144 Free PMC article.

4

Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion.

Briggs E, Crouch K, Lemgruber L, Lapsley C, McCulloch R. Briggs E, et al. Among authors: lemgruber l. PLoS Genet. 2018 Dec 13;14(12):e1007729. doi: 10.1371/journal.pgen.1007729. eCollection 2018 Dec. PLoS Genet. 2018. PMID: 30543624 Free PMC article.

5

Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation.

Briggs E, Crouch K, Lemgruber L, Hamilton G, Lapsley C, McCulloch R. Briggs E, et al. Among authors: lemgruber l. Nucleic Acids Res. 2019 Sep 26;47(17):9180-9197. doi: 10.1093/nar/gkz644. Nucleic Acids Res. 2019. PMID: 31350892 Free PMC article.

6

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens.

Black JA, Crouch K, Lemgruber L, Lapsley C, Dickens N, Tosi LRO, Mottram JC, McCulloch R. Black JA, et al. Among authors: lemgruber l. Cell Rep. 2020 Jan 21;30(3):836-851.e5. doi: 10.1016/j.celrep.2019.12.049. Cell Rep. 2020. PMID: 31968257 Free PMC article.

7

Genome maintenance functions of a putative Trypanosoma brucei translesion DNA polymerase include telomere association and a role in antigenic variation.

Leal AZ, Schwebs M, Briggs E, Weisert N, Reis H, Lemgruber L, Luko K, Wilkes J, Butter F, McCulloch R, Janzen CJ. Leal AZ, et al. Among authors: lemgruber l. Nucleic Acids Res. 2020 Sep 25;48(17):9660-9680. doi: 10.1093/nar/gkaa686. Nucleic Acids Res. 2020. PMID: 32890403 Free PMC article.

8

PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.

Grewal JS, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, Lemgruber L, Gould MK, Burchmore RJ, Coombs GH, Schnaufer A, Mottram JC. Grewal JS, et al. Among authors: lemgruber l. J Biol Chem. 2016 Apr 29;291(18):9492-500. doi: 10.1074/jbc.M116.714972. Epub 2016 Mar 3. J Biol Chem. 2016. PMID: 26940875 Free PMC article.

9

Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.

Cerone M, Uliassi E, Prati F, Ebiloma GU, Lemgruber L, Bergamini C, Watson DG, de A M Ferreira T, Roth Cardoso GSH, Soares Romeiro LA, de Koning HP, Bolognesi ML. Cerone M, et al. Among authors: lemgruber l. ChemMedChem. 2019 Mar 22;14(6):621-635. doi: 10.1002/cmdc.201800790. Epub 2019 Feb 5. ChemMedChem. 2019. PMID: 30664325 Free PMC article.

10

A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii.

Melatti C, Pieperhoff M, Lemgruber L, Pohl E, Sheiner L, Meissner M. Melatti C, et al. Among authors: lemgruber l. PLoS Pathog. 2019 Apr 4;15(4):e1007512. doi: 10.1371/journal.ppat.1007512. eCollection 2019 Apr. PLoS Pathog. 2019. PMID: 30947298 Free PMC article.

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