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Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells.
Speziali G, Liesinger L, Gindlhuber J, Leopold C, Pucher B, Brandi J, Castagna A, Tomin T, Krenn P, Thallinger GG, Olivieri O, Martinelli N, Kratky D, Schittmayer M, Birner-Gruenberger R, Cecconi D. Speziali G, et al. Among authors: leopold c. J Proteomics. 2018 Jun 15;181:118-130. doi: 10.1016/j.jprot.2018.04.008. Epub 2018 Apr 12. J Proteomics. 2018. PMID: 29654920
Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D. Radović B, et al. Among authors: leopold c. Diabetologia. 2016 Aug;59(8):1743-52. doi: 10.1007/s00125-016-3968-6. Epub 2016 May 6. Diabetologia. 2016. PMID: 27153842 Free PMC article.
Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.
Leopold C, Duta-Mare M, Sachdev V, Goeritzer M, Maresch LK, Kolb D, Reicher H, Wagner B, Stojakovic T, Ruelicke T, Haemmerle G, Hoefler G, Sattler W, Kratky D. Leopold C, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr;1864(4):500-511. doi: 10.1016/j.bbalip.2019.01.007. Epub 2019 Jan 9. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30639734 Free PMC article.
Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro.
Goeritzer M, Bernhart E, Plastira I, Reicher H, Leopold C, Eichmann TO, Rechberger G, Madreiter-Sokolowski CT, Prasch J, Eller P, Graier WF, Kratky D, Malle E, Sattler W. Goeritzer M, et al. Among authors: leopold c. Int J Mol Sci. 2020 Feb 9;21(3):1143. doi: 10.3390/ijms21031143. Int J Mol Sci. 2020. PMID: 32050431 Free PMC article.
Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.
Maresch LK, Benedikt P, Feiler U, Eder S, Zierler KA, Taschler U, Kolleritsch S, Eichmann TO, Schoiswohl G, Leopold C, Wieser BI, Lackner C, Rülicke T, van Klinken J, Kratky D, Moustafa T, Hoefler G, Haemmerle G. Maresch LK, et al. Among authors: leopold c. Hepatol Commun. 2018 Dec 17;3(2):227-245. doi: 10.1002/hep4.1292. eCollection 2019 Feb. Hepatol Commun. 2018. PMID: 30766961 Free PMC article.
Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover.
Grumet L, Eichmann TO, Taschler U, Zierler KA, Leopold C, Moustafa T, Radovic B, Romauch M, Yan C, Du H, Haemmerle G, Zechner R, Fickert P, Kratky D, Zimmermann R, Lass A. Grumet L, et al. Among authors: leopold c. J Biol Chem. 2016 Aug 19;291(34):17977-87. doi: 10.1074/jbc.M116.724054. Epub 2016 Jun 27. J Biol Chem. 2016. PMID: 27354281 Free PMC article.
153 results