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Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.
Li M, Wang Y, Zheng XB, Ikeda M, Iwata N, Luo XJ, Chong SA, Lee J, Rietschel M, Zhang F, Müller-Myhsok B, Cichon S, Weinberger DR, Mattheisen M, Schulze TG, Martin NG, Mitchell PB, Schofield PR, Liu JJ, Su B; MooDS Consortium. Li M, et al. Schizophr Res. 2012 Dec;142(1-3):200-5. doi: 10.1016/j.schres.2012.10.008. Epub 2012 Oct 25. Schizophr Res. 2012. PMID: 23102693
The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors.
Luo XJ, Li M, Huang L, Nho K, Deng M, Chen Q, Weinberger DR, Vasquez AA, Rijpkema M, Mattay VS, Saykin AJ, Shen L, Fernández G, Franke B, Chen JC, Chen XN, Wang JK, Xiao X, Qi XB, Xiang K, Peng YM, Cao XY, Li Y, Shi XD; Alzheimer’s Disease Neuroimaging Initiative; Gan L, Su B. Luo XJ, et al. Among authors: li y, li m. PLoS One. 2012;7(11):e50375. doi: 10.1371/journal.pone.0050375. Epub 2012 Nov 30. PLoS One. 2012. PMID: 23226269 Free PMC article.
Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.
Luo XJ, Mattheisen M, Li M, Huang L, Rietschel M, Børglum AD, Als TD, van den Oord EJ, Aberg KA, Mors O, Mortensen PB, Luo Z, Degenhardt F, Cichon S, Schulze TG, Nöthen MM; iPSYCH-GEMS SCZ working group; MooDS SCZ Consortium; Su B, Zhao Z, Gan L, Yao YG. Luo XJ, et al. Among authors: li m. Schizophr Bull. 2015 Nov;41(6):1294-308. doi: 10.1093/schbul/sbv017. Epub 2015 Mar 10. Schizophr Bull. 2015. PMID: 25759474 Free PMC article.
Further evidence of VRK2 rs2312147 associated with schizophrenia.
Chang H, Zhang C, Xiao X, Pu X, Liu Z, Wu L, Li M. Chang H, et al. Among authors: li m. World J Biol Psychiatry. 2016 Sep;17(6):457-66. doi: 10.1080/15622975.2016.1200746. Epub 2016 Jul 6. World J Biol Psychiatry. 2016. PMID: 27382989
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