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Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.
Egger LA, Kidambi U, Cao J, Van Riper G, McCauley E, Mumford RA, Amo S, Lingham R, Lanza T, Lin LS, De Laszlo SE, Young DN, Kopka IE, Tong S, Pikounis B, Benson E, Warwood S, Bargatze RF, Hagmann WK, Schmidt JA, Detmers PA. Egger LA, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62. doi: 10.1124/jpet.302.1.153. J Pharmacol Exp Ther. 2002. PMID: 12065712
Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).
Treonze KM, Alves K, Fischer P, Hagmann WK, Hora D, Kulick A, Vakerich K, Smith ND, Lingham RB, Maniar S, Reger TS, Zunic J, Munoz B, Prasit P, Nicholson D, Si Q, Judd K, Nicolich S, Kellerhouse P, Thompson D, Mumford RA. Treonze KM, et al. Among authors: lingham rb. Vet Immunol Immunopathol. 2009 Jul 15;130(1-2):79-87. doi: 10.1016/j.vetimm.2009.01.011. Epub 2009 Feb 4. Vet Immunol Immunopathol. 2009. PMID: 19250687
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Venkatraman S, Lebsack AD, Alves K, Gardner MF, James J, Lingham RB, Maniar S, Mumford RA, Si Q, Stock N, Treonze KM, Wang B, Zunic J, Munoz B. Venkatraman S, et al. Among authors: lingham rb. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. doi: 10.1016/j.bmcl.2009.07.111. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19713111
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.
Reger TS, Zunic J, Stock N, Wang B, Smith ND, Munoz B, Green MD, Gardner MF, James JP, Chen W, Alves K, Si Q, Treonze KM, Lingham RB, Mumford RA. Reger TS, et al. Among authors: lingham rb. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1173-6. doi: 10.1016/j.bmcl.2009.12.009. Epub 2009 Dec 4. Bioorg Med Chem Lett. 2010. PMID: 20022493
Influence of acid surrogates toward potency of VLA-4 antagonist.
Venkatraman S, Lim J, Cramer M, Gardner MF, James J, Alves K, Lingham RB, Mumford RA, Munoz B. Venkatraman S, et al. Among authors: lingham rb. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4053-6. doi: 10.1016/j.bmcl.2005.06.034. Bioorg Med Chem Lett. 2005. PMID: 16039122
54 results