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Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.
Crippa V, D'Agostino VG, Cristofani R, Rusmini P, Cicardi ME, Messi E, Loffredo R, Pancher M, Piccolella M, Galbiati M, Meroni M, Cereda C, Carra S, Provenzani A, Poletti A. Crippa V, et al. Among authors: loffredo r. Sci Rep. 2016 Mar 10;6:22827. doi: 10.1038/srep22827. Sci Rep. 2016. PMID: 26961006 Free PMC article.
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
Licata NV, Cristofani R, Salomonsson S, Wilson KM, Kempthorne L, Vaizoglu D, D'Agostino VG, Pollini D, Loffredo R, Pancher M, Adami V, Bellosta P, Ratti A, Viero G, Quattrone A, Isaacs AM, Poletti A, Provenzani A. Licata NV, et al. Among authors: loffredo r. EMBO J. 2022 Jan 4;41(1):e105026. doi: 10.15252/embj.2020105026. Epub 2021 Nov 18. EMBO J. 2022. PMID: 34791698 Free PMC article.
Multilayer and MATR3-dependent regulation of mRNAs maintains pluripotency in human induced pluripotent stem cells.
Pollini D, Loffredo R, Maniscalco F, Cardano M, Micaelli M, Bonomo I, Licata NV, Peroni D, Tomaszewska W, Rossi A, Crippa V, Dassi E, Viero G, Quattrone A, Poletti A, Conti L, Provenzani A. Pollini D, et al. Among authors: loffredo r. iScience. 2021 Feb 16;24(3):102197. doi: 10.1016/j.isci.2021.102197. eCollection 2021 Mar 19. iScience. 2021. PMID: 33733063 Free PMC article.
Targeting the multifaceted HuR protein, benefits and caveats.
Zucal C, D'Agostino V, Loffredo R, Mantelli B, NatthakanThongon, Lal P, Latorre E, Provenzani A. Zucal C, et al. Among authors: loffredo r. Curr Drug Targets. 2015;16(5):499-515. doi: 10.2174/1389450116666150223163632. Curr Drug Targets. 2015. PMID: 25706256 Review.
In vitro and in vivo inhibition of proangiogenic retinal phenotype by an antisense oligonucleotide downregulating uPAR expression.
Lulli M, Cammalleri M, Granucci I, Witort E, Bono S, Di Gesualdo F, Lupia A, Loffredo R, Casini G, Dal Monte M, Capaccioli S. Lulli M, et al. Among authors: loffredo r. Biochem Biophys Res Commun. 2017 Aug 26;490(3):977-983. doi: 10.1016/j.bbrc.2017.06.150. Epub 2017 Jun 27. Biochem Biophys Res Commun. 2017. PMID: 28666875