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108 results

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Page 1
Synthesis of 6,6- and 7,7-Difluoro-1-acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO.
Panth N, Wenger ES, Krebs C, Bollinger JM Jr, Grossman RB. Panth N, et al. Chembiochem. 2022 Jul 5;23(13):e202200081. doi: 10.1002/cbic.202200081. Epub 2022 May 17. Chembiochem. 2022. PMID: 35482316 Free PMC article.
By contrast, LolO was able to hydroxylate 7,7-difluoro-AcAP (prepared from 3-oxoproline) but failed to cycloetherify it, forming (1R,2R,8S)-7,7-difluoro-2-hydroxy-AcAP as the sole product. The divergent LolO-catalyzed reactions of the difluorinated AcAP analogues pr …
By contrast, LolO was able to hydroxylate 7,7-difluoro-AcAP (prepared from 3-oxoproline) but failed to cycloetherify it, forming (1R, …
Pathology in Practice.
Polledo L, De Garnica MG, Schoenauer R, Weber K, Alonso J, Lolo S, Waine K. Polledo L, et al. J Am Vet Med Assoc. 2022 Mar 16;260(9):1009-1012. doi: 10.2460/javma.20.06.0319. J Am Vet Med Assoc. 2022. PMID: 35298400 Free article. No abstract available.
Lolo's no choke.
Gregory S. Gregory S. Time. 2012 Jul 30;180(5):30-6, 38. Time. 2012. PMID: 22950306 No abstract available.
A new peridural needle-the 'LOLO' needle.
Delima LK, Delima DF. Delima LK, et al. J Postgrad Med. 1989 Apr;35(2):74-8. J Postgrad Med. 1989. PMID: 2621665 Free article.
This ideal function is only possible if the bevel and tip of the needle are not inversely related as is the case in circular cross section needles. The 'LOLO' peridural needle developed by us is free of this compromise. ...
This ideal function is only possible if the bevel and tip of the needle are not inversely related as is the case in circular cross section n …
Machine learning models accurately predict ozone exposure during wildfire events.
Watson GL, Telesca D, Reid CE, Pfister GG, Jerrett M. Watson GL, et al. Environ Pollut. 2019 Nov;254(Pt A):112792. doi: 10.1016/j.envpol.2019.06.088. Epub 2019 Jul 5. Environ Pollut. 2019. PMID: 31421571
Gradient boosting was the most accurate of the ten machine learning algorithms with the lowest LOLO CV estimated root mean square error (0.228) and the highest LOLO CV R(2) (0.677). Random forest was the second best performing algorithm with an LOLO CV R(2) o …
Gradient boosting was the most accurate of the ten machine learning algorithms with the lowest LOLO CV estimated root mean square err …
Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions.
Pan J, Bhardwaj M, Zhang B, Chang WC, Schardl CL, Krebs C, Grossman RB, Bollinger JM Jr. Pan J, et al. Biochemistry. 2018 Apr 10;57(14):2074-2083. doi: 10.1021/acs.biochem.8b00157. Epub 2018 Mar 29. Biochemistry. 2018. PMID: 29537853 Free PMC article.
Here we show that LolO is, in fact, solely responsible for this biosynthetic four-electron oxidation. ...When supplied with substoichiometric 2OG, LolO only hydroxylates AcAP. At higher 2OG:AcAP ratios, the enzyme further processes the alcohol to the tricyclic NANL. …
Here we show that LolO is, in fact, solely responsible for this biosynthetic four-electron oxidation. ...When supplied with substoich …
Autophagy and the Lysosomal System in Cancer.
Kumar S, Sánchez-Álvarez M, Lolo FN, Trionfetti F, Strippoli R, Cordani M. Kumar S, et al. Cells. 2021 Oct 14;10(10):2752. doi: 10.3390/cells10102752. Cells. 2021. PMID: 34685734 Free PMC article. Review.
Phthalate esters in clothing: A review.
Aldegunde-Louzao N, Lolo-Aira M, Herrero-Latorre C. Aldegunde-Louzao N, et al. Environ Toxicol Pharmacol. 2024 Apr 25;108:104457. doi: 10.1016/j.etap.2024.104457. Online ahead of print. Environ Toxicol Pharmacol. 2024. PMID: 38677495 Free article. Review.
Ether bridge formation in loline alkaloid biosynthesis.
Pan J, Bhardwaj M, Faulkner JR, Nagabhyru P, Charlton ND, Higashi RM, Miller AF, Young CA, Grossman RB, Schardl CL. Pan J, et al. Phytochemistry. 2014 Feb;98:60-8. doi: 10.1016/j.phytochem.2013.11.015. Epub 2013 Dec 26. Phytochemistry. 2014. PMID: 24374065 Free PMC article.
Genomes of endophytes differing in alkaloid profiles were sequenced, revealing that those with mutated lolO accumulated exo-1-acetamidopyrrolizidine but no lolines. Heterologous expression of wild-type lolO complemented a lolO mutant, resulting in the product …
Genomes of endophytes differing in alkaloid profiles were sequenced, revealing that those with mutated lolO accumulated exo-1-acetami …
108 results