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811 results

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Page 1
N-acyl phenylalanine analogues as potent small molecule VLA-4 antagonists.
Chen L, Tilley JW, Huang TN, Miklowski D, Trilles R, Guthrie RW, Luk K, Hanglow A, Rowan K, Schwinge V, Wolitzky B. Chen L, et al. Among authors: luk k. Bioorg Med Chem Lett. 2000 Apr 17;10(8):725-7. doi: 10.1016/s0960-894x(00)00088-3. Bioorg Med Chem Lett. 2000. PMID: 10782673
A new series of potent oxindole inhibitors of CDK2.
Luk KC, Simcox ME, Schutt A, Rowan K, Thompson T, Chen Y, Kammlott U, DePinto W, Dunten P, Dermatakis A. Luk KC, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):913-7. doi: 10.1016/j.bmcl.2003.12.009. Bioorg Med Chem Lett. 2004. PMID: 15012993
Identification of novel, potent and selective inhibitors of Polo-like kinase 1.
Chen S, Bartkovitz D, Cai J, Chen Y, Chen Z, Chu XJ, Le K, Le NT, Luk KC, Mischke S, Naderi-Oboodi G, Boylan JF, Nevins T, Qing W, Chen Y, Wovkulich PM. Chen S, et al. Among authors: luk kc. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1247-50. doi: 10.1016/j.bmcl.2011.11.052. Epub 2011 Dec 1. Bioorg Med Chem Lett. 2012. PMID: 22172702
Synthesis of potent oxindole CDK2 inhibitors.
Dermatakis A, Luk KC, DePinto W. Dermatakis A, et al. Bioorg Med Chem. 2003 Apr 17;11(8):1873-81. doi: 10.1016/s0968-0896(03)00036-1. Bioorg Med Chem. 2003. PMID: 12659774
Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Anderson K, Chen Y, Chen Z, Dominique R, Glenn K, He Y, Janson C, Luk KC, Lukacs C, Polonskaia A, Qiao Q, Railkar A, Rossman P, Sun H, Xiang Q, Vilenchik M, Wovkulich P, Zhang X. Anderson K, et al. Among authors: luk kc. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5. doi: 10.1016/j.bmcl.2013.10.055. Epub 2013 Nov 1. Bioorg Med Chem Lett. 2013. PMID: 24239188
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
Padilla F, Bhagirath N, Chen S, Chiao E, Goldstein DM, Hermann JC, Hsu J, Kennedy-Smith JJ, Kuglstatter A, Liao C, Liu W, Lowrie LE Jr, Luk KC, Lynch SM, Menke J, Niu L, Owens TD, O-Yang C, Railkar A, Schoenfeld RC, Slade M, Steiner S, Tan YC, Villaseñor AG, Wang C, Wanner J, Xie W, Xu D, Zhang X, Zhou M, Lucas MC. Padilla F, et al. J Med Chem. 2013 Feb 28;56(4):1677-92. doi: 10.1021/jm301720p. Epub 2013 Feb 12. J Med Chem. 2013. PMID: 23350847
(2,3)-alpha-Methylenepenams: synthesis and in vitro activity.
Wei CC, Luk KC, West KF, Roberts JL, Pruess D, Moore DW, Yang R, Steppe T, Rossman P, Weigele M, et al. Wei CC, et al. Among authors: luk kc. Bioorg Med Chem. 1993 Sep;1(3):173-82. doi: 10.1016/s0968-0896(00)82118-5. Bioorg Med Chem. 1993. PMID: 8081849
Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.
McDermott LA, Higgins B, Simcox M, Luk KC, Nevins T, Kolinsky K, Smith M, Yang H, Li JK, Chen Y, Ke J, Mallalieu N, Egan T, Kolis S, Railkar A, Gerber L, Liu JJ, Konzelmann F, Zhang Z, Flynn T, Morales O, Chen Y. McDermott LA, et al. Among authors: luk kc. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. doi: 10.1016/j.bmcl.2005.12.092. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16460940
Rational design of highly selective spleen tyrosine kinase inhibitors.
Lucas MC, Goldstein DM, Hermann JC, Kuglstatter A, Liu W, Luk KC, Padilla F, Slade M, Villaseñor AG, Wanner J, Xie W, Zhang X, Liao C. Lucas MC, et al. J Med Chem. 2012 Dec 13;55(23):10414-23. doi: 10.1021/jm301367c. Epub 2012 Nov 27. J Med Chem. 2012. PMID: 23151054
811 results