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Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.
Lees JA, Ferwerda B, Kremer PHC, Wheeler NE, Serón MV, Croucher NJ, Gladstone RA, Bootsma HJ, Rots NY, Wijmega-Monsuur AJ, Sanders EAM, Trzciński K, Wyllie AL, Zwinderman AH, van den Berg LH, van Rheenen W, Veldink JH, Harboe ZB, Lundbo LF, de Groot LCPGM, van Schoor NM, van der Velde N, Ängquist LH, Sørensen TIA, Nohr EA, Mentzer AJ, Mills TC, Knight JC, du Plessis M, Nzenze S, Weiser JN, Parkhill J, Madhi S, Benfield T, von Gottberg A, van der Ende A, Brouwer MC, Barrett JC, Bentley SD, van de Beek D. Lees JA, et al. Among authors: madhi s. Nat Commun. 2019 May 15;10(1):2176. doi: 10.1038/s41467-019-09976-3. Nat Commun. 2019. PMID: 31092817 Free PMC article.
Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South Africa.
du Plessis M, von Gottberg A, Madhi SA, Hattingh O, de Gouveia L, Klugman KP; Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA). du Plessis M, et al. Int J Antimicrob Agents. 2008 Nov;32 Suppl 1:S66-70. doi: 10.1016/j.ijantimicag.2008.06.002. Epub 2008 Aug 23. Int J Antimicrob Agents. 2008. PMID: 18723328
An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa.
Mothibeli KM, du Plessis M, von Gottberg A, de Gouveia L, Adrian P, Madhi SA, Klugman KP; Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA). Mothibeli KM, et al. J Clin Microbiol. 2010 Jan;48(1):184-91. doi: 10.1128/JCM.01011-09. Epub 2009 Nov 4. J Clin Microbiol. 2010. PMID: 19889905 Free PMC article.
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