Madin A - Search Results

1

Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters.

Mateu N, Kidd SL, Kalash L, Sore HF, Madin A, Bender A, Spring DR. Mateu N, et al. Among authors: madin a. Chemistry. 2018 Sep 12;24(51):13681-13687. doi: 10.1002/chem.201803143. Epub 2018 Aug 13. Chemistry. 2018. PMID: 30011115 Free PMC article.

2

Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.

Twigg DG, Kondo N, Mitchell SL, Galloway WR, Sore HF, Madin A, Spring DR. Twigg DG, et al. Among authors: madin a. Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12479-83. doi: 10.1002/anie.201606496. Epub 2016 Sep 6. Angew Chem Int Ed Engl. 2016. PMID: 27596095 Free PMC article.

3

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.

Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, von Delft F, Dowson CG, Spring DR. Kidd SL, et al. Among authors: madin a. Chem Sci. 2020 May 14;11(39):10792-10801. doi: 10.1039/d0sc01232g. Chem Sci. 2020. PMID: 34094333 Free PMC article.

4

High Fidelity Suzuki-Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants.

Hunter JH, Prendergast L, Valente LF, Madin A, Pairaudeau G, Waring MJ. Hunter JH, et al. Among authors: madin a. Bioconjug Chem. 2020 Jan 15;31(1):149-155. doi: 10.1021/acs.bioconjchem.9b00838. Epub 2020 Jan 6. Bioconjug Chem. 2020. PMID: 31873005

5

Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries.

Hunter JH, Anderson MJ, Castan IFSF, Graham JS, Salvini CLA, Stanway-Gordon HA, Crawford JJ, Madin A, Pairaudeau G, Waring MJ. Hunter JH, et al. Among authors: madin a. Chem Sci. 2021 Jun 22;12(27):9475-9484. doi: 10.1039/d1sc03007h. eCollection 2021 Jul 14. Chem Sci. 2021. PMID: 34349922 Free PMC article.

6

Functional Group Tolerance of a Micellar on-DNA Suzuki-Miyaura Cross-Coupling Reaction for DNA-Encoded Library Design.

Hunter JH, Potowski M, Stanway-Gordon HA, Madin A, Pairaudeau G, Brunschweiger A, Waring MJ. Hunter JH, et al. Among authors: madin a. J Org Chem. 2021 Dec 17;86(24):17930-17935. doi: 10.1021/acs.joc.1c02259. Epub 2021 Nov 24. J Org Chem. 2021. PMID: 34816720

7

Scope of on-DNA nucleophilic aromatic substitution on weakly-activated heterocyclic substrates for the synthesis of DNA-encoded libraries.

Castan IFSF, Madin A, Pairaudeau G, Waring MJ. Castan IFSF, et al. Among authors: madin a. Bioorg Med Chem. 2022 Jun 1;63:116688. doi: 10.1016/j.bmc.2022.116688. Epub 2022 Mar 25. Bioorg Med Chem. 2022. PMID: 35430536 Free article.

8

Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and High Selectivity.

Collie GW, Clark MA, Keefe AD, Madin A, Read JA, Rivers EL, Zhang Y. Collie GW, et al. Among authors: madin a. J Med Chem. 2024 Jan 25;67(2):864-884. doi: 10.1021/acs.jmedchem.3c01861. Epub 2024 Jan 10. J Med Chem. 2024. PMID: 38197367 Free PMC article. Review.

9

Discovery of a selective c-MET inhibitor with a novel binding mode.

Collie GW, Barlind L, Bazzaz S, Börjesson U, Dale IL, Disch JS, Habeshian S, Jetson R, Khurana P, Madin A, Michaelides IN, Peng L, Snijder A, Stubbs CJ. Collie GW, et al. Among authors: madin a. Bioorg Med Chem Lett. 2022 Nov 1;75:128948. doi: 10.1016/j.bmcl.2022.128948. Epub 2022 Aug 17. Bioorg Med Chem Lett. 2022. PMID: 35987508 Free article.

10

Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.

Read J, Collie IT, Nguyen-McCarty M, Lucaj C, Robinson J, Conway L, Mukherjee J, McCall E, Donohoe G, Flavell E, Peciak K, Warwicker J, Dix C, Van den Hoven BG, Madin A, Brown DG, Moss S, Haggarty SJ, Brandon NJ, Bürli RW. Read J, et al. Among authors: madin a. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1962-1967. doi: 10.1016/j.bmcl.2019.05.032. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31153805

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